Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Militaris Tertiae》 2010-20
Add to Favorite Get Latest Update

Preparation and characterization of oridonin phospholipid complex

Lu Guoqing1,2,Zheng Jiang3,Zheng Xinchuan3,Lu Yonglin3,He Fengci1(1Division of Scientific Research Affairs,3Medical Research Center,Southwestern Hospital,Third Military Medical University,Chongqing,400038;2 Department of Clinical Pharmacy,General Hospital of Chengdu Military Command,Chengdu,Sichuan Province,610083,China)  
Objective To prepare and characterize oridonin phospholipid complex.MethodsOridonin phospholipid complex was prepared by solvent evaporation.The thermodynamic properties of oridonin phospholipid complex were studied by differential scanning calorimetry.The state of oridonin in the complex was studied by X-ray diffraction.Whether new chemical bonds existed were studied by UV-VIS spectrophotometry.The dispersion of oridonin phospholipid complex in water was studied through observing crystals of oridonin by microscopy.ResultsThe peak of melting point changed in the DSC spectra.The crystallogram showed that oridonin dispersed in an amorphous form in phospholipid,meanwhile the peaks of crystal diffraction disappeared.There was no new chemical bonds appearance.The oridonin phospholipid complex was instable and could easily separate crystals out in water.ConclusionWe successfully prepare oridonin phospholipid complex,but the system is instable in water,so can not be used as drug delivery system for oridonin alone.
【CateGory Index】: R283
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 3 Hits
1 DING Dong-mei1,2,ZHANG Zhen-hai2,JIANG Yan-rong2,JIA Xiao-bin1,2(1.School of Pharmacy,Jiangsu University,Zhenjiang 212013,China; 2.Key Laboratory of Drug Delivery System of Chinese Meteria Medica under State Administration of Traditional Chinese Medicine,Jiangsu Provincial Academy of Chinese Medicine,Nanjing 210028,China);Advance in studies on phospholipid compound of traditional Chinese medicines[J];China Journal of Chinese Materia Medica;2013-13
2 HAO Hai-jun;ZHANG Hong-qin;JIA You-zhi;HAN Ru;WANG Hang;State Key Laboratory of New Drug and Pharmaceutical Process,Shanghai Institute of Pharmaceutical Industry;National Engineering Research Center for Traditional Chinese Medicine;The 152 Central Hospital of PLA;;Progress in research on enhancing dissolution and bioavailability of Chinese materia medica-phospholipid complex with new preparation techniques[J];Chinese Traditional and Herbal Drugs;2013-17
3 CHEN Xiaojin;YAN Jun;WANG Hong;ZHAO Ya;The Children's hospital of Hangzhou;Zhejiang Medical College;The sixth People's hospital of Hangzhou 310014;;Study on Skin Permeation of Diammonium Glycyrrhizinate Phospholipid Complex Gel[J];Chinese Archives of Traditional Chinese Medicine;2013-10
Chinese Journal Full-text Database 2 Hits
1 HE Jing, WANG Zhang yang, LIU Song qing (Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Preparation of gliclazide-hydroxypropyl-β-cyclodextrin inclusion complexes[J];Acta Academiae Medicinae Militaris Tertiae;2004-11
2 XU Wen,SUN Jin,ZHANG Ting-ting,MA Bo,CHEN Da-wei,HE Zhong-gui (School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China);Determination of equilibrium solubility of oridonin and its apparent oil/water partition coefficient by HPLC[J];Journal of Shenyang Pharmaceutical University;2007-04
Chinese Journal Full-text Database 10 Hits
1 WANG Yong-xue et al(Pharmaceutical Laboratory,Xinxiang Medical College,Xinxiang,Henan 453003);Quantitative Determination of Oridonin in Isodon macrophyllus by RP-HPLC[J];Journal of Anhui Agricultural Sciences;2008-22
2 LIU Chen et al (College of Biological Science and Engineering,Hebei University of Science and Technology,Shijiazhuang,Hebei 050018);Effects of Rare Earth Elements on the Synthesis of Rubescensin A in Robdosia rubescens Cell[J];Journal of Anhui Agricultural Sciences;2009-13
3 LU Xiu-xia,HE Lin,CHEN Li,WU Wei-ang,SHI Rui-biao,LONG Xiao-ying(Guangdong Pharmaceutical College,Zhongshan,Guangdong 528458,China);Determination of equilibrium solubility and oil-water partition coefficient of scutellarin[J];Journal of Guangdong Pharmaceutical College;2011-01
4 Ning Yu,Zhao Peirong,Lian Xiaoke,Wang Liuxing,Wang Ruilin,Fan Qingxia,Sun Yan (Tumor Center of Zhengzhou University,Zhengzhou 450052,China);Quantitative Determination of Oridonin in Human Plasma by RP-HPLC[J];Journal of Basic and Clinical Oncology;2006-03
5 YAN Xuebin~ 1) , ZHANG Jianye~ 1) , KE Yu~ 2) , ZHOU Xia~ 1) , LIU Hongmin~ 2) 1)Department of Chemistry, Zhengzhou University, Zhengzhou 450001 2)College of Pharmacy, Zhengzhou University, Zhengzhou 450001;Synthesis of amino-derivatives of oridonin and their antitumor activity[J];Journal of Zhengzhou University(Medical Sciences);2007-01
6 Li,Meirong Cai,Xiaoqing Zhu,Yifeng Liu,Kuanguan Hu,Maolin(College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou 325035);Synthesis and Biological Evaluation of Novel Coupling Derivatives of Photosensitizer and 5-fluorouracil as Antineoplastic Agents[J];Acta Chimica Sinica;2011-04
7 LI Bao-hong 1,ZHANG Li-jian 2,DONGYE Guang-zhi 2,DENG Yi-feng 1,LIANG Nian-ci 1 (1.Key Laboratory of Natural Drugs Research and Development of Guangdong,Guangdong Medical College,Zhanjiang 524023,China;2.Center Lab of Guangdong Medical College,Zhanjiang 524023,China);Study on the solid dispersion of quercetin-PEG6000[J];West China Journal of Pharmaceutical Sciences;2004-01
8 WEI Wei,ZHAO Dong,ZHANG Zhi-Rong,GONG Tao(Key Laboratory of Drug Targeting,Ministry of Education West China School of Pharmacy,Sichuan University,Chengdu 610041,China);Study on the physico-chemical properties of hydroxycamptothecin-phospholipid complex[J];West China Journal of Pharmaceutical Sciences;2008-04
9 HE Qing1,YANG Qin1,GONG Tao1,ZHANG Zhi-rong1,DENG Li1,ZHANG Yan2(1.Key Laboratory of Drug Targeting and Novel Drug Delivery Systems,Ministry of Education,West China School of Pharmacy,Sichuan University,Chengdu,Sichuan,610041 P.R.China;2.Chongqing Yaoyou Pharmaceutical Co.,Ltd.,Chongqing,401121 P.R.China);Preparation of long-circulating oridion-containing micelle and its pharmacokinetics[J];West China Journal of Pharmaceutical Sciences;2012-01
10 WANG Chuan-jin,WEI Yun-yang,L Jing,DU Yang-yan (School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing 210094,Jiangsu,China);Isolation of Oridonin from Rabdosia Rubescens Hemsl by Preparative High Performance Liquid Chromatography[J];Fine Chemicals;2007-07
Chinese Journal Full-text Database 10 Hits
1 LI Yan-zhen,YAN Hui,LIU Huan,JIN Wen-xian,WANG Cheng-gang State Key Laboratory of Drug Delivery Technology and Pharmacokinetics,Tianjin Institute of Pharmaceutical Research,Tianjin300193,China;Preparation of vinorelbine-phospholipid complex and its characterization[J];Drugs & Clinic;2012-06
2 TIAN Hui,WANG Ya-jing*,PENG Shu-juan,SUN Shi-zhen(Tianjin University of Traditional Chinese Medicine,Tianjin State Key Laboratory of Modern Chinese Medicine,Tianjing,300193 P.R.China);Study on the permeation properties of Resveratrol phospholipid complex through rat skin in vitro[J];West China Journal of Pharmaceutical Sciences;2011-03
3 GUO Yu-yi,WANG Ling,DU Qing-qing,WANG Zhan-guo,JIANG Xue-hua(West China School of Pharmacy,Sichuan University,Chengdu,Sichuan,610041 P.R.China);Investigation of the absorption mechanism and interactions among active components in Xiexin decoction[J];West China Journal of Pharmaceutical Sciences;2011-04
4 LI Nan1,2,TU Ling2,YE Ying-jie1,YANG Ming3,JIANG Xue-hua2*(1.College of Pharmacy,Chengdu University of TCM,Chengdu,Sichuan,611137 P.R.China;2.West China School of Pharmacy,Sichuan University,Chengdu,Sichuan,610041 P.R.China;3.Key Laboratory of Modern Preparation of TCM,Ministry of Education,Nanchang,Jiangxi,330004 P.R.China);Study on the membrane transport of baicalin-phospholipid complexes by parallel artificial membrane permeability method[J];West China Journal of Pharmaceutical Sciences;2011-06
5 HE Su-na1,WANG Dong-kai1,LI Lin-sui1,LI Lin1,WEN Hong-de2,WANG Xue-li2 (1.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China;2.General Hospital of Shenyang Area,Shenyang 110016,China);Preparation and characterization of docetaxel phospholipid complex submicron emulsion[J];Chinese Journal of Pharmaceutics(On Line);2010-01
6 CHEN Xin-mei,WU Xiao-kun,KONG De-gang,CHEN Song(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China);Preparation and preliminary study of quality evaluation of ginsenosides phospholipid compound[J];Qilu Pharmaceutical Affairs;2011-09
7 Wang Dan~(1,2),Wang Ji~(1,2),Yan Xueying~2,Kuang Haixue~2,Wang Xiangtao~1 (1.Institute of Medicinal Plant Development Office of Pharmacy,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100193,China; 2.Heilongjiang University of Chinese Medicine College of Pharmacy,Harbin 150040,China);Preparation and Characterization of Phytosomes of Total Flavonoids of Flos Daturae[J];World Science and Technology(Modernization of Traditional Chinese Medicine and Materia Medica);2010-05
8 ZHOU Chong,DU Li-yuan,LIN Dong-hai,SUN Xiu-yan(School of Pharmacy,Yantai University,Yantai 264005,China);Absorption of the phospholipid complex of zedoary turmeric oil in rats intestine using in situ single pass perfusion model[J];Journal of Shenyang Pharmaceutical University;2011-10
9 LUO Ya-jun1,2,ZHANG Qi2,3,ZHANG Xin-shen2,and LEI Yu11)Chemistry & Chemical Engineering College,Mianyang Normal University Mianyang 621000 Sichuan Province P.R.China2)School of Light Industry and Textile and Foodstuff Engineering,Sichuan University Chengdu 610065 P.R.China3)College of Life Science and Technology,Southwest University for Nationalities,Chengdu 610041 P.R.China;Preparation and spectrum investigation of daidzein-phospholipid complex[J];Journal of Shenzhen University Science and Engineering;2010-02
10 TIAN Hui,WANG Ya-jing,SUN Shi-zhen,WANG Yan-ming,PENG Shu-juan,GAO Xu(Tianjin University of TCM,Tianjin State Key Laboratory of Modern Chinese Medicine,Tianjin 300193,China);Study on preparation method of mangiferin phospholipid complex[J];Tianjin Journal of Traditional Chinese Medicine;2012-01
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 YANG Sheng-li, HAN Shao-yin, ZHANG Qiao, DING Lan-ping, SONG Ai-yun, GONG Ya-ou, ZHANG Tan-mu (Department of Esophageal Cancer Research, Henan Medical University, Zhengzhou 450052, China);STUDY ON THE ANTIMUTAGENICTTY OF ORIDONIN[J];Carcinogenesis,Teratogenesis and Mutagenesis;2001-01
3 Wang Mian-ying and zhang Tan-mu Department Pharmacology, Henan Medical Research Institute, Zhengzhou;STUDY OF THE MECHANISM OF ACTION OF RUBE SCENSINE A ON M PHASE OF SEVERAL TUMOR CELLS[J];Chinese Journal of Cancer;1984-02
4 Feng Changwei; Pan Xianglin; Zou Junhui; et al (the Affiliated Hospital of Shandong Medical University, Jinan 250012);Study on Inhibition of Human HL-60 Cell Growth by Oridonin[J];JOURNAL OF ZHEJIANG COLLEGE OF TCM;2000-03
6 Zhao Wei Harbin No.6 Phamaceutical Factory(150056);The New Method for Preparing Oridonin by Medium Pressure Column Chromatography[J];Heilongjiang Medical Journal;2001-01
7 Shou Magang, et al Department of pharmacology, Henan Medical Institute;Study of the effet of oridonin and bleomycin A_5 combination therapy on the cell cycle of Ehrlich carcinoma cells by means of the flow cytometry[J];;1985-02
8 Wang Mianying, et al Department of pharmacology, Henan Medical Research Institute;Microphotometric and autoradiographic studies of cytokinetic effects of oridonin on L_(1210) and S_(180) cells[J];;1986-01
9 Yang, Yan-Wu Xu, Xiao-Long~* Wang, De-Hua Qian, Bao-Gong (Laboratory of Magnetic Resonance and Atomic and Molecular Physios, Wuhan Institute of Physics, Academia Sinca, Wuhan 430071) Zhao, Qing-Zhi Ji, Ang (Department of Chemistry, Henan University of Medical Science, Zhengzhou, 450053);Studies of Molecular Configuration of Oridonin by 2D-NMR[J];Acta Chimica Sinica;1992-05
10 Feng Changwei,Pan Xianglin,Zou Junhui,et al (7);Iuduction of Apoptosis in HL-60 Cells by Oridonin[J];SHANDONG MEDICAL JOURNAL;2000-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved