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《Acta Academiae Medicinae Militaris Tertiae》 2010-20
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Preparation and characterization of oridonin phospholipid complex

Lu Guoqing1,2,Zheng Jiang3,Zheng Xinchuan3,Lu Yonglin3,He Fengci1(1Division of Scientific Research Affairs,3Medical Research Center,Southwestern Hospital,Third Military Medical University,Chongqing,400038;2 Department of Clinical Pharmacy,General Hospital of Chengdu Military Command,Chengdu,Sichuan Province,610083,China)  
Objective To prepare and characterize oridonin phospholipid complex.MethodsOridonin phospholipid complex was prepared by solvent evaporation.The thermodynamic properties of oridonin phospholipid complex were studied by differential scanning calorimetry.The state of oridonin in the complex was studied by X-ray diffraction.Whether new chemical bonds existed were studied by UV-VIS spectrophotometry.The dispersion of oridonin phospholipid complex in water was studied through observing crystals of oridonin by microscopy.ResultsThe peak of melting point changed in the DSC spectra.The crystallogram showed that oridonin dispersed in an amorphous form in phospholipid,meanwhile the peaks of crystal diffraction disappeared.There was no new chemical bonds appearance.The oridonin phospholipid complex was instable and could easily separate crystals out in water.ConclusionWe successfully prepare oridonin phospholipid complex,but the system is instable in water,so can not be used as drug delivery system for oridonin alone.
【CateGory Index】: R283
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