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《Journal of Third Military Medical University》 2011-14
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Expression and prognostic significance of PPAR-γ and PTEN protein in hepatocellular carcinoma

Zhang Meng,He Hongtao,Zhou Ye,Xu Zhuo,Yang Tao,Liang Zhanqiang,Peng Li(Department of Hepatobiliary Surgery,Fourth Hospital,Hebei Medical University,Shijiazhuang,Hebei Province,050011,China)  
Objective To explore the expression of peroxisome proliferator-activated receptor γ(PPAR-γ) and phosphatase and tensin homology deleted on chromosome ten(PTEN) protein in hepatocellular carcinoma(HCC),and to elucidate their clinical significance.Methods Immunohistochemical analysis was performed to detect the expression of PPAR-γ and PTEN protein in 78 specimens of HCC tissues and 21 specimens of normal hepatic tissues.The relationship of their expression with the clinicopathological characteristics and prognosis of HCC was analyzed.Results The positive expression rate of PPAR-γ(51.3%) in HCC tissues was significantly higher than that(19.0%) in normal hepatic tissues(P0.05).The high expression rate of PTEN in HCC tissues(42.3%) was significantly lower than that(90.5%) in normal hepatic tissue(P0.05).The PPAR-γ expression was correlated with tumor size and portal vein tumorous thrombus(P0.05) as well as tumor-node-metastasis(TNM) stage(P0.01).The PTEN expression was correlated with tumor size,portal vein tumorous thrombus,and invasion or lymph node metastasis(P0.05) as well as TNM stage(P0.01).No significant correlation was observed between PPAR-γ expression and PTEN expression in HCC tissues(r=-0.100,P=0.384).Patients with low PTEN expression had significantly worse postoperative survival than those with high PTEN expression(P=0.000,Log-rank test).However,PPAR-γ expression was not significantly correlated with the postoperative survival of HCC patients(P=0.175,Log-rank test).A multivariate analysis based on COX regression model demonstrated that TNM stage was an independent factor affecting prognosis of HCC.Conclusion The expression levels of PPAR-γ and PTEN protein are closely related to the malignant biological behavior of HCC.PTEN is helpful to evaluate prognosis.
【Fund】: 河北省普通高校强势特色学科建设基金(2005-52);; 河北省卫生厅资助课题(06142)~~
【CateGory Index】: R735.7
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7 WU Xu-dong1,CHEN Wei-chang2,ZHANG Su-qing2(1.Department of Gastroenterology,First Affiliated Hospital of Soochow University,Suzhou 215006,China; 2.Department of General Surgery,Tumor Hospital,Nantong 226361,China);The association of expression of peroxisome proliferator-activated receptor γ with microcirculation of intra-hepatocellular carcinoma[J];Tumor;2007-11
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