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《Journal of Third Military Medical University》 2011-14
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Expression and prognostic significance of PPAR-γ and PTEN protein in hepatocellular carcinoma

Zhang Meng,He Hongtao,Zhou Ye,Xu Zhuo,Yang Tao,Liang Zhanqiang,Peng Li(Department of Hepatobiliary Surgery,Fourth Hospital,Hebei Medical University,Shijiazhuang,Hebei Province,050011,China)  
Objective To explore the expression of peroxisome proliferator-activated receptor γ(PPAR-γ) and phosphatase and tensin homology deleted on chromosome ten(PTEN) protein in hepatocellular carcinoma(HCC),and to elucidate their clinical significance.Methods Immunohistochemical analysis was performed to detect the expression of PPAR-γ and PTEN protein in 78 specimens of HCC tissues and 21 specimens of normal hepatic tissues.The relationship of their expression with the clinicopathological characteristics and prognosis of HCC was analyzed.Results The positive expression rate of PPAR-γ(51.3%) in HCC tissues was significantly higher than that(19.0%) in normal hepatic tissues(P0.05).The high expression rate of PTEN in HCC tissues(42.3%) was significantly lower than that(90.5%) in normal hepatic tissue(P0.05).The PPAR-γ expression was correlated with tumor size and portal vein tumorous thrombus(P0.05) as well as tumor-node-metastasis(TNM) stage(P0.01).The PTEN expression was correlated with tumor size,portal vein tumorous thrombus,and invasion or lymph node metastasis(P0.05) as well as TNM stage(P0.01).No significant correlation was observed between PPAR-γ expression and PTEN expression in HCC tissues(r=-0.100,P=0.384).Patients with low PTEN expression had significantly worse postoperative survival than those with high PTEN expression(P=0.000,Log-rank test).However,PPAR-γ expression was not significantly correlated with the postoperative survival of HCC patients(P=0.175,Log-rank test).A multivariate analysis based on COX regression model demonstrated that TNM stage was an independent factor affecting prognosis of HCC.Conclusion The expression levels of PPAR-γ and PTEN protein are closely related to the malignant biological behavior of HCC.PTEN is helpful to evaluate prognosis.
【Fund】: 河北省普通高校强势特色学科建设基金(2005-52);; 河北省卫生厅资助课题(06142)~~
【CateGory Index】: R735.7
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 ZHANG Meng,PENG Li,MIAO Zhan-jun,XU Zhuo,WANG Shun-xiang,TANG Rui-feng,ZHANG Feng-rui,WANG Shi-jieDepartment of Hepatobiliary Surgery,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China;Effect of Rosiglitazone on Expression of VEGF in Liver Cancer Cell Line SMMC-7721[J];Cancer Research on Prevention and Treatment;2010-03
2 Guo Minglei, Li Jingjun, LI Hongnian, WAN Da fang, Gu Jianren. (Department of Biochemistry , Shanghai Cancer Institute,Shanghai 200032,China);Enhanced expression of peroxisome proliferator-activated receptor γ in liver cancer[J];Tumor;2005-05
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 YANG Han-zheng,WU Xu-dong1,CHEN Wei-chang2(Institute of Immunology,Yancheng Health Vocational & Technical College,Yancheng 224006;1Department of Gastroenterology,the First People Hospital of Yancheng,Yancheng 224006;2Department of Gastroenterology,the First Affiliated Hospital of SooChow University,Suzhou 215006,China);PPARγ knockdown inhibited cell invasion and metastasis of HCCLM3 cells[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2008-07
2 WU Xu-dong1,CHEN Wei-chang1,ZHU Shu-yang2,YE Jian-xin1 1.Department of Gastroenterology,First affiliated Hospital of Soochow University,Suzhou 215006,P.R.China2.Department of Pediatrics,North Courtyard of First People's Hospital of Chenzhou City,Chenzhou 423000,P.R.China;Effect of RNA interference targeting at peroxisome proliferator-activated receptor gamma gene on angiogenesis of hepatocellular carcinoma in nude mice[J];Chinese Journal of Cancer Prevention and Treatment;2009-07
3 WU Xudong,CHEN Weichang,ZHANG Suqing.Department of Gastroenterology,Affiliated First Hospital,Soochow University, Suzhou 215006, CHINA;The expression and clinical significance of PPARγ in hepatocellular carcinoma[J];Jiangsu Medical Journal;2007-11
4 Xudong Wu~1 Weichang Chen~2 Suqing Zhang~3 1 Department of Gastroenterology,The First People Hospital of Yancheng,Yancheng 224006,China 2 Department of Gastroenterology,The First Affiliated Hospital,Soochow University,Suzhou 215006,China 3 Department of Surgery,Tumor Hospital of Nantong,Nantong 226361,China;Peroxisome proliferator-activated receptorγexpression correlates with tumor angiogenesis in human hepatocellular carcinoma[J];中德临床肿瘤学杂志(英文版);2008-05
5 HE Kun,HU Ze-ming,ZHOU Zai-ping,CHEN Hong,DENG Hui-zhou The First Department of General Surgery,Zhongshan City People's Hospital (Zhongshan Affiliated Hospital of Sun Yat-Sen University), Zhongshan 528400,China;Different Expression and Significance of PPARγ in Hepatocellular Carcinoma[J];Cancer Research on Prevention and Treatment;2009-12
6 ZHAO Yong,ZHANG Ling,LI Cui-ling,YIN Hai-peng,GU Hong-tao,WEN Pei-e(Institute of Basic Medicine,Key Medical Laboratory for Tumor Immunology and Chinese Medicine Immunology of Shandong Province,Key Laboratory for Modern Medicine and Technology of Shandong Province,Shandong Academy of Medical Science,Ji′nan 250062,Shandong,China);Autocrined VEGF regulates mCRPs expressions in lung cancer cells and the related mechanisms[J];Chinese Journal of Cancer Biotherapy;2010-03
7 WU Xu-dong1,CHEN Wei-chang2,ZHANG Su-qing2(1.Department of Gastroenterology,First Affiliated Hospital of Soochow University,Suzhou 215006,China; 2.Department of General Surgery,Tumor Hospital,Nantong 226361,China);The association of expression of peroxisome proliferator-activated receptor γ with microcirculation of intra-hepatocellular carcinoma[J];Tumor;2007-11
8 WU Xu-dong1,CHEN Wei-chang2,HUANG Xiao-ping2(1.Department of Gastroenterology,First People's Hospital of Yancheng City,Yancheng 224001,China;2.Department of Gastroenterology,First Affiliated Hospital of Soochow University,Suzhou 215006,China);Silencing PPARγ gene inhibits proliferation and inducs apoptosis of hepatoma HCCLM3 cells[J];Tumor;2008-08
9 MA Xiu-mei,YU Hong,HUAI Na (Department of Pathology, Inner Mongolia Medical College, Huhht 0100590,China);Effect of silencing PPARγ by RNA interference on growth of human gastric carcinoma cells[J];Tumor;2008-10
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