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《Journal of Third Military Medical University》 2011-18
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Effect of resveratrol on pulmonary vurus titer and airway inflammation in mice infected with respiratory syncytial virus

Zang Na1,Xie Xiaohong2,Deng Yu2,Li Simin1,Ni Ke1,Luo Yan1,Wang Lijia1,Liu Enmei2(1Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,2Department of Respiratory Medicine,Children's Hospital,Chongqing Medical University,Chongqing,400014,China)  
Objective To study the effect of resveratrol(RES) on pulmonary virus titer and airway inflammation in mice infected with respiratory syncytial virus(RSV).Methods Twenty-four female BALB/c mice at the age of 6-8 weeks,treated with intra-abdominal cyclophosphamide(CYP) at the dose of 100 mg/kg,were randomly divided into control group,RSV infection group,and RES treatment group(8 in each group).Five days after CYP treatment,a RES infection model was induced by intranasal drip of RES.One hour after RES infection,the mice received intraperitoneal injection of RES or inhaled it at the dose of 30mg/(kg·d).Five days later,airway hyper-response(AHR) in lucid mice was detected.The mice were then killed to detect the pulmonary RSV titers in the lung,the number of cells in bronchoalevolar lavage fluid(BALF),inflammation in lung tissue and its score.Results The pulmonary RSV titer,the number of cells in BALF,the score of inflammation in lung tissue,and the airway AHR were significantly lower in RES treatment group than in RSV infection group(P0.01).However,no significant difference was observed between RES treatment group and control group.Conclusion Differenly administrated RES can relieve RSV-induced inflammation and AHR by reducing pulmonary titer and inhibiting RSV replication in vivo.
【Fund】: 重庆医科大学校办重点课题项目(XBZD200808);; 教育部新世纪优秀人才支持计划(NCET-06-0775);; 重庆市第二批高等学校优秀人才支持计划~~
【CateGory Index】: R285.5
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