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《Journal of Third Military Medical University》 2012-16
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Functional brain mapping with BOLD and DECS in surgical treatment of brain tumors in language areas

Ma Hui1,Huang Wei2,Sun Shengyu2,Xia Hechun2,Sun Xiaochuan1(1Department of Neurosurgery,First Affiliated Hospital of Chongqing Medical University,Chongqing,400016;2Department of Neurosurgery,Affiliated Hospital of Ningxia Medical University,Yinchuan,Nigxia Hui Autonomous Region,750004,China)  
Objective To study the application of cortical mapping methods of blood oxygen level-dependent-magnetic resonance imaging(BOLD-MRI) for preoperative localization of language areas and intrao-perative direct electrical cortical stimulation(DECS) of language areas in awake anesthesia in assisting to remove brain tumors in language areas.Methods Cortical mapping data of language areas was collected from 15 patients with brain tumors in language areas by BOLD-MRI and/or intraoperative DECS in awake anesthesia,and the data combined with neuronavigation assisted-microscopy were applied for the removal of brain tumors in language areas.Results The images of language areas were successfully obtained from the 15 patients by pre-operative BOLD-MRI,and after evaluation the language areas were localized by both preoperative BOLD and intraoperative DECS in 6 patients.There were total resection in 10 patients,subtotal resection in 3 patients and partial resection in 2 patients based on the protection of language areas.After the operation,there were 6 patients with significantly improved language function,5 patients with unchanged language function,2 patients with transient sensory aphasia and 2 patients with deteriorated language function.Conclusion Functional cortical mapping including preoperative BOLD-MRI and intraoperative DECS has a good clinical value for the localization of language areas.It can increase the extent of tumor resection without impairing the language area,reduce postoperative morbidity,and improve the life quality of the patients with brain tumor.
【Fund】: 宁夏自然科学基金(NZ08121)~~
【CateGory Index】: R739.4
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