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《ACTA ACADEMIAE MEDICINAE MILITARIS TERTIAE》 1997-03
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Changes of mycardial mitochondrial respiratory function and ATP content in hypoxic rats

Luo Gang, Zhang Guobing, Xie Zhengzhu, Liu Fuyu (Department of Pathophysiology, Third Military Medical University, Chongqing,630038)  
Objective: To determine the changes of myocardial energy metabolism in hypoxic rats. Method: 30 adult Wistar rats were equally devided into three groups: 1)normal control group; 2)actuhypoxic group; 3)chronichypoxic group. The changes of respiratory function, activity of FoF1ATPase and ANS fluroescense intensity in myocardial mitochondria were observed with clark oxygen electrode and tiochemical method and the content of ATP in myocardial tissue measured with high performance liquid chromatography (HPLC). Results: 1)The respiratory function, FoF1ATPase activity and ANS flurosecense intensity were significantly decreased in acutehypoxic. Though the above parameters were increased in chronichypoxic group as compared with thore in the acutehypoxic group, they remained lower than those in the control. 2)ATP content was positively correlated to PCR, FoF1ATPase activity and PaO2. Conclusion: The failure of myocardial energy metabolism in acutehypoxic rats may be due to the decrease of mitochondrial respiratory. function and ATP production. The improvement of energy metabolism in chronichypoxic rats in one of the mechanisms for hypoxic adjustment.
【Key Words】： hypoxia mitochondrial function FoF1ATPase ATP content rat
【CateGory Index】： R329.24
【DOI】： CNKI:SUN:DSDX.0.1997-03-019
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