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《ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE》 1999-01
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Protective effects of cardioplegia enhanced with N acetylcysteine on the heart in hypothermic ischemia reperfused rats

Xiao Yingbin, Yang Sujuan, Han Benli, Ren Jianping, Tang Zhongming, Liu Yutuan (Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037)  
Objective: To investigate the protective effects of cardioplegia enhanced with N acetylcysteine (NAC) on the heart in hypothermic ischemia reperfused rats. Methods: The rat hearts was arrested by multiple dose of NAC enhanced cardioplegia and St. Thomas solution perfusion respectively for 180 min at 20℃ and reperfused for 60 min. The recovery of cardiac function and energy metabolism was observed. Results: The recovery of cardiac function and energy metabolism was much better in the hearts perfused with NAC enhanced cardioplegia than with St. Thomas solution. Conclusion: The enhancement with NAC can significantly improve the myocardial protective effects of St. Thomas solution, which suggests that NAC might be a valuable additive for hypothermic cardioplegic myocardial protection.
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