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《Journal of The Fourth Military Medical University》 1988-04
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The Study and Application of the Monoclonal Antibodies against Haemorrhagic Fever with Renal Syndrome Virus

Wang Meixian, et al. Department of Microbiology  
It was summarized that the studies and applications of monoclonal antibo-dies(McAb)against haemorrhagic fever with renal syndrome(HFRS)virus were made by our department in past few years. They are (1) establishment and characterization of the hybridoma cell lines secreting McAb against HFRS virus and hemagglutinin of the virus, (2) the antigenic analysis of HFRS viruses in China by the McA-b, (3) purification and application of the McAbs,(4) purification and characterization of HFRS virus 50K structural protein with McAb-affinity chromatography and the McAb possessing different characteristics, (5) detection of HFRS virus antigen in peripheral blood lymphocytes from HFRS patients by the McAb-lFAT, and (6) to develop the McAb-ELlSA indirect sandwich methods, and to detect HFRS virus antigen and IgM, IgG and/or H1 antibodies in human and animals. The results of these studies show that the McAbs can be used for early diagnosis, epidemiological investigation, preparation of vaccine and immunotherapy of HFRS.
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【Citations】
Chinese Journal Full-text Database 10 Hits
1 Xu Zhikai Wang Meixian Jiang Shaochun Ma Wenyu (Department of Microbiology, The Fourth Military Medical College, Xian);DETECTION OF EPIDEMIC HEMORRHAGIC FEVER VIRUS ANTIGEN BY A DOUBLE MONOCLONAL ANTIBODY ELISA INDIRECT SANDWICH METHOD[J];Chinese Journal of Virology;1986-04
2 Xu Zhikai Waug Meixian Wang HaitaoWang Liya Jiang Shaozhun Ma Weiyu(Department of Microbiology, The Fourth Military Medical College,Xian);ANALYSIS OF 50k PROTEIN OF THE VIRUSOF HAEMORRHAGIC FEVER WITH RENALSYNDROME BY MONOCLONAL ANTIBODlES[J];Chinese Journal of Virology;1988-02
3 Xu Zhikai, et al(Department of Microbiology);Detection of IgM and IgG Antibodies in HFRS Patients'Sera by McAb ELISA Indirect Sandwich Method[J];Journal of The Fourth Military Medical University;1986-03
4 Zhang Hongyi(Department of Microbiology);Applied Study of McAb Against Epidemic Hemorrhagic Fever virus (EHFV) in Early Clinical Diagnosis[J];Journal of The Fourth Military Medical University;1987-01
5 Wang Liya, et al. Department of Microbiology;Establishment and Identification of Hybridoma Cell Lines Secreting Monoclonal Antibodies against Hemagglutinin of Hemorrhagic Fevev with Renal Syndrome Virus[J];Journal of The Fourth Military Medical University;1988-01
6 Xu Zhikai, et al. Department of Microbiology;Detection of HFRS Virus Antibodies in Human and Animal Sera from Epidemic Area of the House-Rat Type of HFRS by a McAb-ELISA Indirect Sandwich Method[J];Journal of The Fourth Military Medical University;1988-03
7 Wang Liay, et al. Department of Microbiology;Detection of Hemagglutination Inhibition Antibodies in HFRS Patient's Sera by a McAb-ELISA Indirect Sandwich Method[J];Journal of The Fourth Military Medical University;1988-03
8 An Xianlu, Xu Zhikai, Li Enshan and Zhen Rongfen.Director: Wang Meixian. Fourth Military Medical College, Xi-anJiang Kejian and Gan Rihuai. Health and Anti-epidemic Station of Shanxi, Xi-an;ESTABLISHMENT AND IDENTIFICATION OF HYBRIDOMA CELL OF MONOCLONAL AN-TIBODIES FOR VIRUS OF HEMORRHAGIC FEVERS WITH RENAL SYNDROME(HFRS)[J];Medical Journal of Chinese People's Liberation Army;1984-04
9 Xu Zhi-kai(Department of Microbiology, Fouth Military Medical College, Xian);Purification and Characterization of HFRS Virus 50K Structural Protein[J];Virologica Sinica;1988-02
10 Tang Jia Qi,et al Military Medical Research Institute,Nan Jing Command;PRODUCTION AND CHARACTERIZATION OF THE MONOCLONAL ANTIBODIES AGAINST HEMORRHAGIC FEVER WITH RENAL SYNDROME VIRUS[J];Chinese Journal of Immunology;1988-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Xu Zhikai Wang Meixian Jiang Shaochun Ma Wenyu (Department of Microbiology, The Fourth Military Medical College, Xian);DETECTION OF EPIDEMIC HEMORRHAGIC FEVER VIRUS ANTIGEN BY A DOUBLE MONOCLONAL ANTIBODY ELISA INDIRECT SANDWICH METHOD[J];Chinese Journal of Virology;1986-04
2 Xu Zhikai Waug Meixian Wang HaitaoWang Liya Jiang Shaozhun Ma Weiyu(Department of Microbiology, The Fourth Military Medical College,Xian);ANALYSIS OF 50k PROTEIN OF THE VIRUSOF HAEMORRHAGIC FEVER WITH RENALSYNDROME BY MONOCLONAL ANTIBODlES[J];Chinese Journal of Virology;1988-02
3 Liang Mifang Song Can Hang Changshou Li Dexing Qiu Huilin(Institute of Virology, Chinese Academy of Preventive Medicine, Beijing);PRELIMINARY STUDY ON STRUCTURAL PROTEIN OF EPIDEMIC HEMORRHAGIC FEVER VIRUS USING MONOCLONAL ANTIBODIES[J];Chinese Journal of Virology;1989-03
4 Huang Qiquan Wang Meixian (Department of Microbiology, The Fourth Military Medical College, Xian);PROTECTION OF MONOCLONAL ANTIBODY FOR HFRS VIRUS INFECTED MICE[J];Chinese Journal of Virology;1990-02
5 Nie Zilin Yu Yongxin( National Institute for Control of Pharmaceutical and Biological Products, Beijing );CYTOPATHIC EFFECT ( CPE ) ON VERO CELLS OF VIRUSES OF HAEMORRHAGIC FEVER WITH RENAL SYNDROME ( HFRS ) DERIVED FROM DIFFERENT SOURCES[J];Chinese Journal of Virology;1991-02
6 Cheng Yun(Department of Microbiology);Preparation of Biotin - Avidin Labled Proteins to Establish BA - ELISA and Its Preliminary Application[J];Journal of The Fourth Military Medical University;1987-02
7 Wang Liya, et al. Department of Microbiology;Establishment and Identification of Hybridoma Cell Lines Secreting Monoclonal Antibodies against Hemagglutinin of Hemorrhagic Fevev with Renal Syndrome Virus[J];Journal of The Fourth Military Medical University;1988-01
8 Xu Zhikai, et al. Department of Microbiology;Detection of HFRS Virus Antibodies in Human and Animal Sera from Epidemic Area of the House-Rat Type of HFRS by a McAb-ELISA Indirect Sandwich Method[J];Journal of The Fourth Military Medical University;1988-03
9 Wang Liay, et al. Department of Microbiology;Detection of Hemagglutination Inhibition Antibodies in HFRS Patient's Sera by a McAb-ELISA Indirect Sandwich Method[J];Journal of The Fourth Military Medical University;1988-03
10 An Xianlu, et al. Department of Microbiology;Establishment of Group-Specific McAb Suitable for Labelling against HFRSV and Application[J];Journal of The Fourth Military Medical University;1988-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Tan Fu-lai et al;Immuno-Blotting Analysis on Polypeptides of Epidemic Hemorrhagic Fever Virus (EHFV)[J];Anhui Medical Journal;1988-05
2 Chen Boquan Ni Dashi Shen Hongkai Zhou NingYao Yixin Sun Yueying Wu Meiying Liu QinzhiMen Qingrong Song Gan Institute of Virology, Chinese Academy of preventive Medicine.Institute of Anhwei Medical Sciences.Institute of Basic Medical Sciences, Chinese Academy of Medical. Sciences;STUDIES ON THE BIOLOGICAL CHARACTERISTICS OF MONOCLONAL ANTIBODIES AGAINST VIRUS OF HEMORRHAGIC FEVER WITH RENAL SYNDROME( HFRSV )[J];Chinese Journal of Virology;1987-03
3 Liang Mifang Song Gan Hang Changshu Li Dexin Li Yingying (Institute of Virology, Chinese Academy of Preventive Medicine, Beijing);ANTIGENiC EPITOPE ANALYSIS OF THE NUCLEOCAPSID PROTEIN OF EPIDEMIC HEMORRHAGIC FEVER VIRUS USING MONOCLONAL ANTIBODIES[J];Chinese Journal of Virology;1989-01
4 Liang Mifang Song Can Hang Changshou Li Dexing Qiu Huilin(Institute of Virology, Chinese Academy of Preventive Medicine, Beijing);PRELIMINARY STUDY ON STRUCTURAL PROTEIN OF EPIDEMIC HEMORRHAGIC FEVER VIRUS USING MONOCLONAL ANTIBODIES[J];Chinese Journal of Virology;1989-03
5 Li Lee Chen Boquan(Institute of Virology Chinese Academy of Preventive Medicine, Beijing );PRODUCTION OF BISPECIFIC MONOCLONAL ANTIBODIES ANTI-HFRSV-ANTI-HRP[J];Chinese Journal of Virology;1989-04
6 Li Dexin Song Gan Hang Changshou Liang Mifang Zhang Quanfu(Institute of Virology, Chinese Academy of Preventive Medicine, Beijing );STUDIES ON THE STRUCTURAL PROTEINS OF EPIDEMIC HEMORRHAGIC FEVER VIRUS[J];Chinese Journal of Virology;1990-02
7 Huang Qiquan Wang Meixian (Department of Microbiology, The Fourth Military Medical College, Xian);PROTECTION OF MONOCLONAL ANTIBODY FOR HFRS VIRUS INFECTED MICE[J];Chinese Journal of Virology;1990-02
8 Zhang Zhiqing Yao Lihong Hou Yunde(National Laboratory of Molecular Virology and Genetic Engineering, Institute of Virology, Chinese Academy of Preventive Medicine, Beijing );CONSTRUCTION AND APPLICATION OF A HIGH LEVEL EXPRESSION VECTOR CONTAINING P_RP_L PROMOTER[J];Chinese Journal of Virology;1990-02
9 Wang Liya, et al. Department of Microbiology;Establishment and Identification of Hybridoma Cell Lines Secreting Monoclonal Antibodies against Hemagglutinin of Hemorrhagic Fevev with Renal Syndrome Virus[J];Journal of The Fourth Military Medical University;1988-01
10 Tang Yongming, et al. Department of Infectious Diseases, Tangdu Hospital;Relationship between Epidemic Hemorrhagic Fever Virus Infection and the Changes of Subsets and Functions of Peripheral Blood Lymphocytes[J];Journal of The Fourth Military Medical University;1988-03
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Xu Zhikai Wang Meixian Jiang Shaochun Ma Wenyu (Department of Microbiology, The Fourth Military Medical College, Xian);DETECTION OF EPIDEMIC HEMORRHAGIC FEVER VIRUS ANTIGEN BY A DOUBLE MONOCLONAL ANTIBODY ELISA INDIRECT SANDWICH METHOD[J];Chinese Journal of Virology;1986-04
2 Chen Boquan Liu Qinzhi Sun Yueying Wu Meiying Zhou Guofang Meng Qingrong Sun Uanxian Qi Ming Li Tairan Xing Zheng Son Gan Institute of Virology, Chinese Academy of Preventive Medicine; Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences; Institute of Biological Product of Beijing.;USE OF MONOCLONAL ANTIBODY SENSITIZED RED BLOOD CELL FOR REVERSE PASSIVE HEMAGGLUTINATION TEST AND REVERSE PASSIVE HEMAGGLUTINATION INHIBITION TEST FOR RAPID DIAGNOSIS OF EPIDEMIC HEMORRHAGIC FEVER[J];Chinese Journal of Virology;1986-04
3 Zhang Hong-yi, et al(Department of Microbiology);RAPID EARLY DIAGNOSIS OF HEMORRHAGIC FEVER WITH RENAL SYNDROME (HFRS)[J];Journal of The Fourth Military Medical University;1985-03
4 Xu Zhikai, et al(Department of Microbiology);Detection of IgM and IgG Antibodies in HFRS Patients'Sera by McAb ELISA Indirect Sandwich Method[J];Journal of The Fourth Military Medical University;1986-03
5 Xia Dongxiang(Department of Microbiology);Application of Micro-Hemagglutination Inhi-bition Test to the Sero-Diagnosis of Hemorrhagic Fever with Renal Syndrome[J];Journal of The Fourth Military Medical University;1987-05
6 Wang Liya, et al. Department of Microbiology;Establishment and Identification of Hybridoma Cell Lines Secreting Monoclonal Antibodies against Hemagglutinin of Hemorrhagic Fevev with Renal Syndrome Virus[J];Journal of The Fourth Military Medical University;1988-01
7 Xu Zhikai, et al. Department of Microbiology;Detection of HFRS Virus Antibodies in Human and Animal Sera from Epidemic Area of the House-Rat Type of HFRS by a McAb-ELISA Indirect Sandwich Method[J];Journal of The Fourth Military Medical University;1988-03
8 An Xianlu, Xu Zhikai, Li Enshan and Zhen Rongfen.Director: Wang Meixian. Fourth Military Medical College, Xi-anJiang Kejian and Gan Rihuai. Health and Anti-epidemic Station of Shanxi, Xi-an;ESTABLISHMENT AND IDENTIFICATION OF HYBRIDOMA CELL OF MONOCLONAL AN-TIBODIES FOR VIRUS OF HEMORRHAGIC FEVERS WITH RENAL SYNDROME(HFRS)[J];Medical Journal of Chinese People's Liberation Army;1984-04
9 Xu Zhi-kai et al (Department of Mirobiology,The Fourth military medi al College,XiAn);Detections of IgM and IgG antibodies in HFRS patient's sera by a McAb ELISA Indirect sandiwich method[J];Chinese Journal of Immunology;1987-01
10 Song Gan, Qiu Xuezhao, Ni Dashi, Zhao Junneng and Kong Bixia et al Institute of Virology, Chinese Academy of Medical Sciences. Beijing. Jiangsu Provincial Anti-epidemic Station, Nanjing. Zhenjiang District Anti-epidemic Station, Jiangsu Province. Danyang County Anti-epidemic Station, Jiangsu Province. Anhui Provincial Institute of Medical Sciences, Hefei.;Etiological Studies of Epidemic Hemorrhagic FeverI. Virus Isolation in Apodemus agrarius from Non-endemic Area and Its Antigenic Characterization[J];Acta Academiae Medicinae Sinicae;1982-02
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