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《Journal of The Fourth Military Medical University》 1988-04
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Detection of the Antigens in Athymic Nude Mice Infected by Hemorrhagic Fever with Renal Syndrome Virus

Xu Zhikai, et al. Department of Microbiology  
Brain, heart, lung, liver, spleen and kidney tissues were obtained from athymic nude mice on various days after intramuscular inoculation with hemorrhagic fever with renal syndrome (HFRS) virus. HFRS virus antigens were detected in the tissues by EL1SA and 1FAT. It was showed that athymic nude mice were of the higher susceptible for HFRS virus. The virus antigens could be regularlly detected from various tissues after infection, and HFRS virus could induce death of the athymic nude mice. It was observed that the distribution of HFRS virus antigens in athymic nude mice was different from that in the suckling mice which were im-munocompetent and the hamsters which were artificialy immunosuppressive, and varied with the progress of the infection. We conclude that athymic nude mice can be used as an adequate animal model for studying HFRS virus.
【Fund】: 国家自然科学基金(0387004)
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【Co-citations】
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