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《Journal of The Fourth Military Medical University》 1990-02
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Effects of Anisodamine on Reperfusion-Induced Arrhythmias and Hemodynamics in Rabbits

YAO Xiu-Juan, YU Bao,Rong and TAN Yue-Hua Department of Pharmacology  
Effects of anisodamine on reperfusion-ind.uced arrhythmias and hemody-namics were investigated in 36 rabbits subjected to coronary artery occlusion followed by reperfusion Anisodamine 0.5, 1.0 and 5.0 ing/kg administered intravenously one minute before reperfusion reduced the incidence of reperfusion arrhythmias in a dose-depen-dent manner. With 5.0 mg/kg of the drug, the incidence dropped from 83% to 12.5% (P0.01). Meanwhile, the recovery of LVSP, LV±(dp/dt)max and LVEDP was enhanced. It was concluded that anisodamine showed beneficial effects in preventing arrhythmias and in improving cardiac performance during reperfusion.
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【Co-citations】
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1 Yang Jun,et al (Department of Putliology ,Zibo No. 2 Medical School);THE INFLUENCE OF ANISODAMINE ON UPTAKE OF CALCIUM BY ISOLATED RAT ISCHEMIC CARDIOMYCYTES[J];Journal of Binzhou Medical College;1991-02
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【Secondary Citations】
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