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《Journal of The Fourth Military Medical University》 1992-05
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Protection by anisodamine against postischemic reperfusion arrhyth-mia and lipid peroxidation in anesthetized rats

YAO Xiu-Juan GUI Yi YU Bao-Rong TAN Yue-Hua and GUO Zheng-Ren Department of Pharmacology Department of Chemistry  
Seventy-two male Wistar rats, weighing 190±21 g (x±S), were randomly divided into seven groups. The left coronary artery occlusion was induced for 5 min followed by reperfusion in anesthetized rats. One min before reperfusion, drugs were given iv to the experimental groups and saline was given iv to the control group. 28 out of 62 rats occurred ventricular arrhythmia and the malondialdehyde (MDA) content in the myocardium increased from 2.70±0.96 to 2.85±0.92 nmol/mg pr (P0.05). However, after reperfusion, all the animals had rhythm disorders, of which 90% were newly developed or exaggerated arrhythmias in the control group. Meanwhile, the MDA content in the reperfused myocardium was 3.93±0.80 nmol/mg pr (P0.05). The total incidence of arrhythmias after reperfusion in groups of anisodamine 3, 5 and 10 mg/kg were 8/10, 5/11 and 3/10, MDA were 3.06±0.56, 2.98±0.50 and 2.90±0.48 nmol/mg pr respectively. Both results showed that it was dose-dependently decreased. SOD showed similar effects. It suggests that the decrease of myocardial lipid peroxidation may contribute to the beneficial effects of anisodamine in reperfusion arrhythmia.
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