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《JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY》 1997-06
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Influence on rabbit fever model and antiviral action of two kinds of MaXingShiGan decotum extract

Zhang Zhonghai;Wang Shenchun;Wang Rujuan;Wu Shaohua;Wang Changhai;Hu Yongwu(Department of Traditional Chinese Medicine,Department of Pharmaceutics, Xijing Hospital,Fourth Military Medical University, Xi'an 710033)  
To indicate aqueous and alcohol extract of MaXingShiGan decotum that take an effect of antipretic and influence on rabbit fever model and anti virus of two kinds of MaXingShiGan decotum extract.Methods: Make fever models with typhoid and paratyphoid vaccine; infect mice with influenza virus F100 and chicken embryo with influenza virus A3; administer aqueueous and alcohol extract of MaXingShiGan decotum to the mice; record temperature of rabbits, lung weight and mortality of mice; observe histological change of lung;take blood agglutination test. Results: MaXingShiGan decotum take an effect of antipretic, and the alcohol extract is more remarkable (P<0.01). MaXingShiGan decotum decrease mortality of mice, and the alcohol extract is more remarkable (P<0. 01 ). MaXingShiGan decotum take more remarkable inhibitive effect for influenza virus A3 (P<0. 05). Conclusion: MaXingShiGan decotum take an effect of antipretic and anti-virus. The alcohol extract take more remarkable effect in antipretic and anti-virus than the aqueous extract, and the aqueous extract take more remarkable effect in inhibition of chicken embryo influenza virus A3 than the alcohol extract.
【CateGory Index】: R285
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