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《Journal of The Fourth Military Medical University》 1998-06
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Alterations of serum peptides in pre-and post-operative patients with esophageal cancer

HU Ai-Ming(Department of Chest Surgery, Chinese PLAAirforce General Hospital, Beijing 100036)ZANC De-An(Department of Chest Surgery, Chinese PLAAirforce General Hospital, Beijing 100036)WEI Hu-Min(Department of Chest Surgery, Chinese PLAAirforce General H  
Aim: To study the alterations of serum peptidesin pre-and post-operative patients with esophageal cancer.Methods: This investigation conducted on 23 patients withadvanced-stage esophageal cancer, including 16 men and 7women with a mean ages of 49. 1 years; also on 27 normalsubjects as controls including 17 men and 10 women with amean ages of 47. 8 years. Samples of fasting blood werecollected before endoscopy respectively. Substance P (SP),beta-endorphin(β-EP ), vasoactive intestinal peptide(VIP), motilin (MTL), gastrin (GT),and fen-enkephalin(LEK) of the sera were measured by radioimmunoassay kit.Results: In the patients, SP(pmol/L, 88. 2±54. 9 vs 38. 7±20. 9, P0. 01) and β-EP (ng/L, 61. 9±26. 6 vs 36. 6±20. 8, P0. 05) of serum, were increased significantly, andgastrin(ng/L, 36. 7 ±23. 3 vs 61. 0 ±22. 5, P0. 05) ofserum were decreased, than those in the normal subjects.Serum SP, β-EP levels correlated negatively with thegastrin (γ=0. 462,0. 459, respectively, P0. 05). Afteroperation, serum β-EP(ng/L, 40. 4±16. 2,P0. 05) weredecreased in the patients. Conclusion: Serum peptides haveclinically significant changes in esophageal cancer patients.
【CateGory Index】: R735.1
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