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《JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY》 1999-10
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A genetic epidemiological study on esophageal cancer in Xi'an

ZHANG Hong Yan 1, YAN Ming Xiao 1, SUN Chang Sheng 1, LI Liang Shou 1, CHENG Qing Shu 2, ZHANG Hong Bo 3, GUO Xiu Gang 3 1Department of Military Epidemiology, Faculty of Military Health Service and Statistics, Fourth Military Medical  
AIM: To evaluate the segregation ratio, the hereditability (h2) and the standardized mortality ratio (SMR) of esophageal cancers in Xi'an (EC). METHODS: A genetic epidemiological case control study was carried out to study the genetic factors of EC in Xi'an. RESULTS: The in cidence of Ⅰ and Ⅱ degree relatives of the cases was 2.95% and 0.64% respectively, significantly higher than that of the relatives of the controls (0.32%). The segregation ratio was 0.0082~0.0294 and the genetic model belonged to polygenetics. The weighed average h2 of Ⅰ and Ⅱ degree relatives was 50.02% and SMR values of 84 EC cases were more than 1 in both Ⅰ and Ⅱ degree relatives. CONCLUSION: The genetic background, though not a main one, is a risk factor of EC in Xi'an.
【Fund】: 国家自然科学基金
【CateGory Index】: R73-31
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