Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY》 2000-03
Add to Favorite Get Latest Update

Expression of p16 and Cyclin D_1 in uterine endometrial carcinomas and its significance

HE Shu Yun, XIN Xiao Yan, WANG Jian, GUO Hui Ling Department of Obstetrics and Gynecology, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China  
AIM To study the expression and significance of p16 and Cyclin D 1 in human uterine endometrial carcinomas. METHODS The expression of p16 and Cyclin D 1 was exa mined in malignant, borderline and benign uterine endometrial tissues by immunohistochemistry SABC methods. Monoclonal antibodies against p16 and Cyclin D 1 were employed. RESULTS The positive rates of p16 expression among the malignant, borderline and benign tumors were 40%, 68% and 0 respectively. Significant difference was observed ( P 0.05) in malignant tumors. The expression of p16 was associated with pathological grades and no association was found with clinical phases. Cyclin D 1 expression was negative in benign tumors and the positive rates in malignant and borderline tumors were 53% and 21% respectively ( P 0.05). In uterine endometrial carcinomas, no association was found between clinical phases and pathological grades. CONCLUSION There is an overexpression of Cyclin D 1 and a lower expression of p16 in uterine endometrial carcinomas and the synergy of the expression of p16 and Cyclin D 1 may contribute to the development of uterine endometrial carcinomas.
【CateGory Index】: R737.33
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 QU Qun, PENG Hui-Xia, ZONG Lu, ZHAO Ling, DUAN Zhao, DU Wen-Xia Department of Gynecology & Obstetrics, Second Hospital, Xi'an Jiaotong University, Xi'an 710004, China;The preparation of anti-CD3/antiCyclinD1, bispecific monoclonal antibodise And killing effect on the endometrial carcinoma cells[J];Journal of The Fourth Military Medical University;2004-18
2 SUN Xiu-li (Department of Obstetrics and Gynecology,Inner Mongolia Hospital,Huhhot 010017 China);Cyclins and Gynecological Tumor[J];Inner Mongolia Medical Journal;2008-04
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Zhou Chunxiao, Sun Jianheng, Lu Shixin, et al. Cancer institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021;Deletion of MTS1/p16 gene in endometrial carcinoma[J];CHINESE JOURNAL OF ONCOLOGY;1997-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHOU Li,HUANG Ping,ZHU An-na(Department of Gynecologic Surgery,Affiliated Tumor Hospital,Shantou University Medical College,Shantou 515031,China);Relationships between Methylation of p16 Gene,Her-2 Expression and Serum CA125 Level with Clinicopathological Characteristics in Endometrial Carcinoma[J];Carcinogenesis,Teratogenesis & Mutagenesis;2009-02
2 Zhao Chunyan,Zhang Yaozheng,Sun Jin [WT5BX]Department of Laboratory,Dalian Medical University,Dalian,China [WT5HZ];Deletion of P16 gene in 16 gynaecological tumors[J];JOURNAL OF DALIAN MEDICAL UNIVERSITY;2000-01
3 Wang Dong, Su Changqing, Ye Yukun, et al. Nanjing 81 Hospital, Nanjing 210002;Deletion of MTS1/p16 gene in human lung cancers[J];Chinese Clinical Oncology;2000-03
4 Zhang Ping, Wu Qingquan . Department of Oncological Surgery, Huaiyin First Hopital, Huaiyin 223000;Relationship between the deletion of the MTS1/p16 gene and the biological character of gastric cancer[J];Chinese Clinical Oncology;2001-01
5 LIU Ping,LI Yu jie,MA Li li,MAN Shu hong (Weifang People's Hospital,the Affiliated Hospital of Weifang Medical College,Weifang 261041,China);The Association between PCNA and bcl-2,P_(16) ,P_(53) Gene Expression in Endometrial Atypical Hyperplasia and in Endometrial Carcinoma[J];Journal of Weifang Medical College;2003-01
6 Li Shufeng1,Cao Xiangrong1,Chen Tao1,Ye Yukun2 (1.College of Life Science,Nanjing Normal University,Nanjing,210097,PRC) (2.The Cancer Center of PLA,the 81st Hospital,Nanjing, 210002,PRC);p16 Gene Deletions and Mutations in Human Primary Cancers[J];Journal of Nanjing Normal University(Natural Science Edition);2001-02
7 LI Shu feng 1,WANG Ying 2, SU Chang qing 3,CAO Xiang rong 2,SHAN Xiang nian 1 (1.Department of Biology,Medical College of Southeast University,Nanjing 210009, China;?2.College of Life Science,Nanjing Normal University,Nanjing 210097,China;?3;Study on the existence state of CDKN2/p16 gene in human primary malignant tumors[J];Journal of Nanjing Railway Medical College;2001-02
8 DONG Bai hua,HOU Gui hua,ZHANG Ping, et al (Dept. of Obstetrics and Gynecology,Qilu Hospital of Shandong University);Safety of long-term placement of intrauterine devices[J];Acta Academiae Medicinae Shandong;2002-05
9 XU Dong-xiao, BAO Jun-cui(Department of Obsterics and Gynecology, Beijing Hosipital of Shenzhen, Shenzhen, 518036,China);The expression of p16 in proliferative endometrium and endometrial carcinoma[J];Journal of Clinical and Experimental Medicine;2005-01
10 WANG Qiong shu,ZHANG Wei,LIU Yuan jiao,Dep artment of Medical Administration,Wuhan General Hospital,Guangzhou Military Co mmand,Wuhan 430070,China;MTS1/p16 protein aberrance expression with gene deleton and 5'CpG island meth ylation in endometrial carcinoma[J];The Journal of Practical Medicine;2005-10
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 HE Jin song, LAI Huan hui, JIANG Li hua, et al.Department of General Surgery, The Peopl e’s Hospital of Yuebei, Guangdong Province, Shaoguan 512026,P.R.China;The expressions of p16, cyclin D1,Cdk4,Rb, andtheir significance in pancreatic carcinoma[J];CHINESE JOURNAL OF CANCER;1999-04
2 Cui Jin Quan, Shi Yi Fu, Zhou Huai Jun Department of Gynecology,Womens Hospital,School of Medicine, Zhejiang University, Hangzhou,Zhejiang,310006, P.R.China;Expression of RFC2 and PCNA in Different Gestational Trophoblastic Diseases[J];Chinese Journal of Cancer;2004-02
3 Feng Fengzhi Xiang Yang Yin Shujie Wan Xirun Yang Xiuyu (Department of Obstetrics and Gyneeology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China);Hydatidiform mole in women aged 40 or more[J];Oncology Progress;2003-01
4 FAN Xin 1, YU Chun Yan 1, ZHAO Yi Ling 2 1Department of Dermatology, Tangdu Hospital, Xi`an 710038, 2Department of Pathology, Faculty of Preclinical Medicine, Fourth Military Medical University, Xi'an 710033, China;Clinical significance and expression of c-myc gene protein in genitalia leukoplakia and squamous cell carcinoma of vulva[J];Journal of The Fourth Military Medical University;2001-24
5 SHEN Zhu 1, YU Chun Yan 1, CUI Da Xiang 2 1Department of Dermatology, Tangdu Hospital, Xi'an 710038, China, 2Institute of Genetic Diagnosis of Chinese PLA, Fourth Military Medical University, Xi'an 710033, China;Rapid detection and genotyping of human papillomavirus in patients with vulvar leukoplakia[J];Journal of The Fourth Military Medical University;2001-24
6 LIU Xin Lan 1, QIN Jing 2, L Huai Sheng 2, ZHANG Jian Zhong 2, WANG Ning Ju 1, LI Rong 3 1Department of Oncology, 2Department of Pathology, Affiliated Hospital, Ningxia Medical College, Yinchuan 750004, China, 3Departmen;Significance of p16 protein expression in gastric cancers[J];Journal of The Fourth Military Medical University;2002-04
7 ZHANG Chao Hui 1, XU Zheng Shun 1, JIAO Long Hua 1, ZHANG Qi Wei 2, ZHANG Li Hong 3 1Department of Pathology & Pathophysiology ,Medical College, Henan University of Science & Technology, 2Department of Pathology , Staff Hospital of Luoyang Bearing Corporation, 3Department of Pathology, Hospital of Breast Disease, Luoyang, 471003, China;Expression of cyclinD1, p16 and Rb in non-small cell lung cancers[J];Journal of The Fourth Military Medical University;2003-14
8 Ma Zhiming,He Qiusha,Yang Dechang, et al Shangqiu People's Hospital,Shangqiu 476100;The Abnormal Expression of p16 Protein in Human Lung Cancer and Its Clinical Significance[J];HENAN JOURNAL OF ONCOLOGY;1999-01
9 Hu Rui *, Yang Jinqiao, Zhou Leilei, Long Qiming, Zhang Shangfu, Zhang Shiyu. *Department of General Surgery, Sichuan Cancer Hospital, Chengdu 610041;Expression of Cyclin D1 Protein in Breast Cancer and Its Clinical Significance[J];Journal of West China University of Medical Sciences;2000-04
10 Xiong Ju, Peng Zhilan, Yang Kaixuan. Department of Obstetrics and Gynecology, The Second Affiliated Hospital, WCUMS, Chengdu 610041, China;Expression of Cell Cycle Associated Proteins Cyclin D1 and P16 in Endometrial Carcinoma and the Correlation between Their Expression Status[J];Journal of West China University of Medical Sciences;2001-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved