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《JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY》 2000-05
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Curcumin inhibits human hepatocarcinoma cell line SMMC-7721

XUE Yan, XIA Tian, ZHAO JianBin, WU ShaoHua, ZHANG ZhongHai, WANG ZongRen Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China  
AIM To investigate the effect of curcumin on human hepatocarcinoma cell line SMMC-7721. METHODS The effect of curcumin on the growth of SMMC-7721 cells was evaluated by MTT assay in vitro, cell cycle analysis and characteristic ultrastructural alterations. RESULTS Curcumin was effective in inhibiting the proliferation of SMMC7721 cells. The IC 50 value was found to be 5.4 mg·L -1 . Cell cycle analysis indicated that curcumin blocked cells in S phase. The inhibitory effect of curcumin was also confirmed by characteristic ultrastructural alterations. CONCLUSION Curcumin inhibits the proliferation of hepatocarcinoma cell line SMMC7721 in vitro mainly by altering the cell cycle and ultrastructure.
【CateGory Index】: R73-36
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