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《Journal of The Fourth Military Medical University》 2001-09
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Protective and therapeutic effects of electroacupuncture on gastric motor disorders and acute gastric mucosal lesions under psychological stress in rats

WANG Jing Jie 1, HUANG Yu Xin 1, GUO Qing Dong 2, QIN Ming 1, GAO Wei 1, WANG Qing Li 1 1Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China, 2Institute of Neurosurgery of Chin  
AIM To test the protective and therapeutic effects of electroacupuncture on gastric motor disorders and acute gastric mucosal lesions under psychological stress in rats. METHODS Ninety six male Sprague Dauley rats were randomly divided into three groups: control group (CG, n =32), psychological stress group (PSG, n =32) and electroacupuncture group (EAG, n =32). Every group was randomly divided into four subgroups (CG, n =32, n =8; PSG, n =32, n =8; EAG, n =32, n =8). Animal model was constructed with impulsive stimulator of high voltage and stable currency stimulating the Chusanli with electroacupuncture. Then spontaneous electroactivity of dorsal motor nucleus of the vagus nerve (DMV) was recorded extracellularly and EGG with the serosa method, and the gastric mucosa injury index was calculated. RESULTS The spontaneous electroactivity from DMV was rarely observed in normal rats. EGG was regular with frequency 3 per minute and amplitude 360~370 μV. Gastric mucosa was normal. Under psychological stress, spontaneous electroactivity from DMV was irregular which did not significantly correlate with time and degree of psychological stress. But we observed that increasing frequency of spontaneous electroactivity from DMV was predominant. EGG was disorderly and irregular. There was no difference in frequency and amplitude of EGG between C group and A group on the 2nd day, the 4th day, the 6th day, the 8th day after psychological stress with stimulating chusanli by electroacupuncture under psychological stress. Gastric mucosal lesion appeared, even did ulcer. The degree of gastric mucosal lesion became more and more serious, and lesion index increased gradually with the continues psychological stress. But gastric mucosal lesion alleviated significantly under psychological stress with electroacupuncture stimulation. And the effect was more significant with the continues electroacupuncture stimulation. There was significant difference in lesion index between C group and B group ( P 0.01 ). The protective rate increased gradually with the electroacupuncture stimulation. CONCLUSION Psychological stress can lead to gastric motor disorders and gastric mucosal lesions, and the correlation is severe. Stimulating Chusanli can impose protective and therapeutic on them.
【Fund】: 国家自然科学基金资助项目! (39970 888)
【CateGory Index】: R573
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