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《Journal of The Fourth Military Medical University》 2001-11
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Biocompatibility of calcium phosphate cement/BMP composite as bone graft material

SUN Ming Lin 1, HU Yun Yu 1, JIA Xin Bing 2, LI Dan 1, LIU Zhong Xiang 3, ZHU De Sheng 4 1Institute of Orthopaedics of Chinese PLA, Xijing Hospital, 3Department of Parasitology, Faculty of Preclinical Medicine, 4Research Cen  
AIM To construct CPC/BMP composite by combining CPC with BMP, and to detect their biocompatibity. METHODS The toxicity, pyrogen, hemolytic activities and immunogen were detected by means of animal test, cell culture, hemolysis test and histochemical technique. RESULTS The composites were found no toxicity and no pyrogen by animal test, no hemolytic activities and couldn't influence the coagulate of blood in vitro . When the materials were grafted into the muscle pounches in the thigh of mice or rabbits, no obvious specific antibodies produced were detected in serum by ELISA, nor were significant immune reaction of foreign body observed by histochemistry technique. The composites were also testified no cytotoxicity in vitor for the proliferation of cultured cells couldn' be inhibited. CONCLUSION The CPC/BMP composite might have good biocompatibility and be safe for clinical use.
【CateGory Index】: R687
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