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《Journal of The Fourth Military Medical University》 2001-12
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Inhibitory effects of anisodamine on lipopolysacchrides attaching to endothelium and inducing NO release

SUN Jun, YAO Xiu Juan, ZHAO De Hua Department of Pharmacology, Faculty of Preclinical Medicine, Fourth Military Medical University, Xi'an 710033, China  
AIM To investigate the effect of anisodamine on lipopolysaccharides attached to the membrane of endothelium and inducing the releasing of nitric oxide (NO). METHODS The bovine aortic endothelial cells (BAEC) were isolated and cultured for study. The lipopolysaccharides (LPS) attached to the membrane of endothelium was detected by immunocytochemistric means. The NO 3 - level which reflected the releasing of NO in culture medium was determined by high performance liquid chromatography. RESULTS Afterbeing treated with LPS, the group incubating with anisodamine showed there had less LPS attached on than the group treated with LPS only. And the NO 3 - level of the group incubating with anisodamine was lower than the group treated with LPS only. And the NO 3 - level of the group incubating with anisodamine was lower than the group treated with LPS only. CONCLUSION This result suggests that anisodamine can significantly inhibit the LPS attached to the membrane of endothelium and inducing the releasing of NO.
【CateGory Index】: R969
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