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Effect of gentiopicroside on liver injury of rats

LI Yan-Qiu1, ZHAO De-Hua2, PAN Bo-Rong3, LI Bao-Guo1, SUN Wen-Ji1, TIAN Qiong2, JIA Min2 1College of Life Science, Northwest University, Xi'an 710069, Chin a; 2Department of Pharmacology, Faculty of Preclinical Medicine, 3D epartment of Oncolog  
AIM To study the protective effect of gentiopicr os ide (GPS), an extractien from gentiana macrophylla Pall, a Chinese medicinal herb, on chemical and immunological liver injuries in rats. METHODS CCl 4, TAA, D-Gal acute liver injury, CCl 4 chronic liver injury, and t he homogeneous immunological liver injury models of the cavy were used. Normal control group, drug model group, positive control group and two or three drug tr eated group were set in each model. The liver injury models of each group were c reated following the demand: Mice were injured by CCl 4 with bean oil of 10 mL ·L -1, 20 mL·kg -1; rats were treated with bean oil of 400 mL·L -1, 3 mL·kg -1; mice were treated by TAA 50 mg·kg -1; rats by D-G al water solution of 160 mL·L -1, 5 mL·kg -1 and all the models were given ip. GPS therapy by muscular injection was used, mice at levels of 150, 75 , 37.5 mg·kg -1, rats of 120, 60, 30 mg·kg -1 and cavy of 120, 48 mg ·kg -1. The levels of ALT and AST in serum were determined and morphologca l changes of the liver were observed. The curative effects of GPS on different liver injuries were evaluated and the possible mechanism was also preliminarily discussed. RESULTS GPS could notably abate serum ALT and AST o f animals which varied acute or chronic liver injuries, and could also relief ve, to some extent, liver tissue piecemoil necrosis, swelling and fatty degenera tion, thus enhancing liver protein synthesis. CONCLUSION GPS ha s a certain protective effect against many kinds of chemical and immunological l iver injuries.
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