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《Journal of The Fourth Military Medical University》 2001-18
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Effect of gentiopicroside on liver injury of rats

LI Yan-Qiu1, ZHAO De-Hua2, PAN Bo-Rong3, LI Bao-Guo1, SUN Wen-Ji1, TIAN Qiong2, JIA Min2 1College of Life Science, Northwest University, Xi'an 710069, Chin a; 2Department of Pharmacology, Faculty of Preclinical Medicine, 3D epartment of Oncolog  
AIM To study the protective effect of gentiopicr os ide (GPS), an extractien from gentiana macrophylla Pall, a Chinese medicinal herb, on chemical and immunological liver injuries in rats. METHODS CCl 4, TAA, D-Gal acute liver injury, CCl 4 chronic liver injury, and t he homogeneous immunological liver injury models of the cavy were used. Normal control group, drug model group, positive control group and two or three drug tr eated group were set in each model. The liver injury models of each group were c reated following the demand: Mice were injured by CCl 4 with bean oil of 10 mL ·L -1, 20 mL·kg -1; rats were treated with bean oil of 400 mL·L -1, 3 mL·kg -1; mice were treated by TAA 50 mg·kg -1; rats by D-G al water solution of 160 mL·L -1, 5 mL·kg -1 and all the models were given ip. GPS therapy by muscular injection was used, mice at levels of 150, 75 , 37.5 mg·kg -1, rats of 120, 60, 30 mg·kg -1 and cavy of 120, 48 mg ·kg -1. The levels of ALT and AST in serum were determined and morphologca l changes of the liver were observed. The curative effects of GPS on different liver injuries were evaluated and the possible mechanism was also preliminarily discussed. RESULTS GPS could notably abate serum ALT and AST o f animals which varied acute or chronic liver injuries, and could also relief ve, to some extent, liver tissue piecemoil necrosis, swelling and fatty degenera tion, thus enhancing liver protein synthesis. CONCLUSION GPS ha s a certain protective effect against many kinds of chemical and immunological l iver injuries.
【CateGory Index】: R285.5
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Chinese Journal Full-text Database 10 Hits
1 LU Qi-qin et al(Northwest Plateau Institute of Biology,Chinese Academy of Sciences,Xining,Qinghai 810008);Chemical constituents and pharmacological activities of Radix Gentianae Macrophyllae[J];Journal of Anhui Agricultural Sciences;2007-29
2 QI Xiang-jun et al(College of Life Science and Engineering,Shaanxi University of Science and Technology,Xi'an,Shaanxi 710021);Preliminary Study on Tissue Culture of Gentiana macrophylla Pall.[J];Journal of Anhui Agricultural Sciences;2008-05
3 BAI Xiao-chao (College of Chemistry & Chemical Engineering,Ningxia Teachers University,Guyuan,Ningxia 756000);Optimization of Water-extraction Technology for Gentiana macrophylla from Liupan Mountain of Ningxia by Orthogonal Design[J];Journal of Anhui Agricultural Sciences;2009-13
4 BAI Xiao-chao(College of Chemistry & Chemical Engineering,Ningxia Teachers University,Guyuan,Ningxia 756000);Optimization of Alcohol-extraction Technology for Gentiana macrophylla from Liupan Mountain of Ningxia by Orthogonal Design[J];Journal of Anhui Agricultural Sciences;2009-31
5 KANG Hui1,YU Shu-xian2,HAO Xiao-xia1 (1.Hebei Zhongrun Pharmaceutical Company Limited,Shijiazhuang Pharmaceutical Group,Shijiazhuang Hebei 050041,China;2.Department of Chemistry,Nanchang University,Nanchang Jiangxi 330031,China);Optimization of the extraction technology of gentiopicroside from gentiana macrophylla pall by ultrasonic wave[J];Hebei Journal of Industrial Science and Technology;2008-03
6 ;Traditional Application and Modern Study of Radix Gentianae[J];Guiding Journal of TCM;2007-10
7 HAO Xiao-xia,YU Shu-xian,HE Chun-lin(Department of Chemistry,Nanchang University,Nanchang 330031,China);Optimization of the Extraction Technology of Gentiopicroside from Gentiana macrophylla Pall by Orthogonal Experiments[J];Lishizhen Medicine and Materia Medica Research;2007-07
8 Wang Haiying1,Yuan Dongping2,Li Fuan3 (1.Qinghai Institute of Vocational Technical Health;2.Nanjing University of Traditional Chinese Medicine;3.Medicine l College of Qinghai University);EFFECTS OF GENTIANA TOTAL GLYCOSIDES ON SEVERAL HUMAN TUMOR CELLS IN VITRO[J];Journal of Qinghai Medical College;2009-03
9 QI Xiang-jun,WANG Wei,CHEN Ru-yi(School of Life Science and Engineering,Shaan xi University of Science & Technology,Xi′an 710021,China);STUDIES ON CALLUS INDUCTION AND PROLIFERATION OF GENTIANA MACROPHYLLA PALL.[J];Journal of Shaanxi University of Science & Technology(Natural Science Edition);2008-01
10 HUANG Xin-hui, LUO Ming-zhi, QI Hao, WANG Zhe-zhi(College of Life Science, Shaanxi Normal University, Xi'an 710062);Proliferation effects of gentiopicroside and other five Traditional Chinese Medicines on SMMC-7721 Human Hepatocarcinoma Cell Line[J];Northwest Pharmaceutical Journal;2004-04
Chinese Journal Full-text Database 10 Hits
1 Yun haixia Shu xiaohe Xiong zengfang Hou yongfang (College of Geography and Life Science,Qinghai Normal University,Xining,810008,China);Recearch Overview of Gentiana of Chinese herbal medicines[J];Anhui Agricultural Science Bulletin;2007-21
2 MA Yu-hua et al(Northwest Plateau Institute of Biology,the Chinese Academy of Sciences,Xining,Qinghai 810008);Research Advances in a Tibetan Medicine-Gentiana straminea[J];Journal of Anhui Agricultural Sciences;2005-09
3 LU Qi-qin et al(Northwest Plateau Institute of Biology,Chinese Academy of Sciences,Xining,Qinghai 810008);Chemical constituents and pharmacological activities of Radix Gentianae Macrophyllae[J];Journal of Anhui Agricultural Sciences;2007-29
4 BAI Xiao-chao et al(College of Chemistry and Chemical Engineering,Ningxia Teachers University,Guyuan,Ningxia 756000);Content Determination of Gentiopicroside in Gentiana macrophylla Pall.Produced from Ningxia by RP-HPLC[J];Journal of Anhui Agricultural Sciences;2008-27
5 GUO Bin,LOU Yong, JIANG Qun, ZHAO Chun-Hui (Agent Department of the third meiners, Hospital of Huainan Mining Groups, Huainan 232001);A study on the extraction process of creat extract[J];Anhui Medical and Pharmaceutical Journal;2002-03
6 YANG Ping, YU Ting xi, MA Run di, YU Li jian*, SU Wei ming, SHAO Hai yan, LIAO Ming neng, HUANG Lai zhen Guangdong Provincial Key Laboratory of Marine Pharmacy,Zhanjiang Ocean University, Zhanjiang 524025,P.R.China;Cell Cycle Arrest and Apoptosis Induced by Tubeimoside in HeLa Cell[J];Chinese Journal of Cancer;2002-04
7 LI Ji-hen, SHANG Guang-dong. (Department of Biopharmaceutics,China Pharmaceutical U niversity,Nanjing210009;Selection of Phenysacetycarbinol-producing yeast Strain[J];Amino Acids & Biotic Resources;2001-01
8 LI Ze-hong 1,CHEN Dan 1,LI Zhen-hua 2 (1.Jilin agriculture university, Changchun 130118;2.People hospitalin Dongliao County, Dongliao 136200);Determination of Nutrient Elements and Amino Acids in Gallus gallus domesticus[J];Amino Acids & Biotic Resources;2002-04
9 Yang Zhi;Determination of contents of gentiopicroside in various parts of Gentiana Cephantha. Fr[J];;1985-05
10 Xiao liuying 1 ,Pan jingqiang 1 , Rao weinong 2 ,et al( 1 Guangzhou Institute of Traditional Chinese and Materia; 2 Guangzhou Hospital of TCM);The Research of Protective Effect of Litchi Seed of Experimental Liver Injury in Mice[J];China Journal of Traditional Chinese Medicine and Pharmacy;2005-01
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 MA Jian-bin et al(College of Geography and Life Sciences,Qinghai Normal University,Xining,Qinghai 810008);Study on the Extraction and Separation of Iridoid Glycosides Function Component in the Above-ground Part of Gentiana macrophylla[J];Journal of Anhui Agricultural Sciences;2008-24
2 WANG Gao-xue1,WANG Jian-fu1,YUAN Ju-lin1,SHEN Ye-hua2,ZHENG Wei2,LI Li3(1 College of Animal Science and Technology,Northwest Sci-Tech University of Agriculture and Forestry,Yangling,Shaanxi 712100,China;2 Department of Chemistry,Northwest University,Xi'an 710069,China;3 Xi'an Hanbao Biologe Company,Xi'an 710069,China);Activity of Sanguinarine from Macleaya cordata to Dactylogyrus and Six Pathogenic Bacteria in Aquaculture[J];Acta Botanica Boreali-Occidentalia Sinica;2007-08
3 CHAI Yi-feng, WU Yu-tian and LI Xiang(Department of Pharmaceutical Analysis, College of Pharmacy, Second Military Medical University, Guohe Road 325, Shanghai 200433), Fenxi Shiyanshi,2004,23(6):71~92;Pharmaceutical Analysis I[J];Analytical Laboratory;2004-06
4 YANG Shu-bin,TAO Yong-mei,YAO Li (Heilongjing University of Chinese Medicine,Harbin 150040,China);Effects of optimization extraction technology of extraction rate of two kind of gentiopicrin in Radix Gentiana[J];Journal of Harbin University of Commerce(Natural Sciences Edition);2007-04
5 CHEN Zhen-hua,LI Hong-yuan,XIE Zhi-ping,et al (School of Public Health,Harbin Medical University,Harbin 150081,China);Antiviral active compound(RG3-1) from radix gentianae and its anti-RSV activity in vitro[J];Journal of Harbin Medical University;2007-04
6 YU Min1,CHEN Hong-wei2,JIAO Lian-qing1,ZHAI Ying1(1.Jilin Academy of Traditional Chinese Medicine,Changchun 130021,China; 2.Changchun University of Technology,Changchun 130021,China);Recent Progress in Celandine Research[J];Special Wild Economic Animal and Plant Research;2008-02
7 WEN Ju CHEN Baotian ZENG Kang et al.;Therapeutic Effect of Modified Xiaofeng Powder for Chronic Urticaria and Its Influence on Serum Eosinophil Count[J];Journal of New Chinese Medicine;2009-10
8 YANG Mingli WANG Xiujun WU Jie WENG Tao(Department of Pharmaceutical Engineering,Wuhan Bioengineering Institute,Wuhan 430415,Hubei,China);Study on Chemical Constituents in Liposoluable Parts of Gentiana apiata N.E.Br.[J];Journal of Wuhan Bioengineering Institute;2008-01
9 LI Lian-fang,LIANG Xiao-yuan,WANG Kou(Yunnan College of TCM,Kunming Yunnan 650200 China);Contents Mensuration of Totalglycosides of Radix Gentianae[J];Journal of Yunnan University of Traditional Chinese Medicine;2006-05
10 ZHAO Lei1,2,LI Zhi-min1,YANG Jun2ZHANG Jin-yu1,JIN Hang1,RAO Gao-xiong1,2(1.Institute of Medicinal Plant of YAAS,Kunming Yunnan 650231,China;2.Yunnan University of TCM,Kunming Yunnan 650200,China);HPLC Determination of Gentiopicroside in the Aerial Parts of Gentiana rigescens Franch.From Different Regions of Yunnan[J];Journal of Yunnan University of Traditional Chinese Medicine;2008-05
China Proceedings of conference Full-text Database 1 Hits
1 XU Guo-liang~1,MA Xiao-xue~1,ZHANG Qi-yun~1,ZENG Zhi-jun~2,HUANG Li-ping~2,YU Ri-yue~2,LIU Hong-ning~1 1 Key Laboratory of Modern Preparation,Ministry of Education Jiangxi University of TCM,Nanchang 330006,Jiangxi, China;2 College of Pharmacy,Jiangxi University of TCM,Nanchang 330006,Jiangxi,China;Metabonomics preliminary study on the urine of radix gentianae administrated rats[A];[C];2009
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