Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of The Fourth Military Medical University》 2002-01
Add to Favorite Get Latest Update

Therapeutic effect of anisodamine, ANP and CGRP on oleic acid induced acute lung injury in rabbits

JIAN Wen 1, QI Hao Wen 1, LI Zhi Chao 2 1Department of Respiratory Medicine, Xijing Hospital, 2Department of Pathophysiology, Faculty of Preclinical Medicine, Fourth Military Medical University, Xi'an 710033, China  
AIM To investigate the effect and preliminary mechanism of anisodamine (654 2), atrial natriuretic peptide (ANP) and calcitonin gene related peptide (CGRP) on acute lung injury (ALI) rabbits induced by oleic acid. METHODS The rabbits were randomly divided into 6 groups: oleic acid group (OA group), treatment groups and control group. The mean pulmonary arterial pressures (mPAP) at different time points were detected by using right ventricular vessel technique. The concentrations of endothelin 1 (ET 1) in plasma and bronchio alveolar lavage fluid (BALF) at different time points were continuously analysed by radioimmunoassay. In the meantime, PaO 2 and content of lung water were also observed. RESULTS Compared with that in the control group, mPAP, concentrations of ET 1 in plasma and BALF and content of lung water of the oleic acid group markedly increased ( P 0.05, P 0.01), whereas their PaO 2 decreased ( P 0.01). After treatment, mPAP (except 654 2 group), levels of ET 1 and content of lung water decreased ( P 0.05, P 0.01), though varied from group to group, on the other hand, PaO 2 increased ( P 0.01). CONCLUSION Intravenous infusion of 654 2, ANP, CGRP may have beneficial effects on ALI induced by oleic acid.
【CateGory Index】: R563.8
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 LI Zhi-Bin,LI Zhi-Chao,YAN Zhi-Qiang,SONG Jing-Chun,ZHAO Peng-Tao Department of Pathophysiology,School of Basic Medicine,Fourth Military Medical University,Xi'an 710033,China;Therapeutic effect of ANP on pulmonary microvascular endothelial cells injury induced by LPS[J];Journal of The Fourth Military Medical University;2005-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Laboratory Cardiopulmonary Endocrinology Gao Xiao-ming, et al;CARDIONATRIN AND EXPERIMENTAL PULMONARY EDEMA IN RATS[J];;1987-02
2 WU Hong Jing, LOU Bin Cheng, HUANG Dai Kun, LIU Qiu Jie (Department of Emergency, Peking Universty People's Hospital, Beijing 100044, China);Clincal study of penehyclidime hydrochloride in the treatment of organic phosphorus poisoning[J];Journal of Beijing Medical University;2001-01
3 Guo Zheng hui, Hong Xin, Mao Bao ling, QIAN Gui sheng, CHEN Zheng tang (Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037,China);Effects of anisodamine on the expression of TNFα and IL-8 in pulmonary tissue of rats with LPS induced acute lung injury[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;2000-05
4 GUO Zhen hui, HONG Xin, MAO Bao ling, QIAN Gui sheng, CHEN Zheng tang (Research Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037,China);Effects of ansodamine on the activation of nuclear factor kappa B in vitro[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;2000-06
5 HOU Yi feng, MAO Bao ling, QIAN Gui sheng, XU Jian cheng (Institute of Respiratory Diseases of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China);Expression of lipopolysaccharide binding protein mRNA in pulmonary tissues of rat with ‘two-hit’ acute lung injury and the protective effects of anisodamine in this event[J];Acta Academiae Medicine Militaris Tertiae;2001-07
6 ZHANG Jian 1, LI Huan Zhang 1, QI Hao Wen 1, HUANG Weng Jing 2, CHEN Bing Fu 2, YIAN Pei Song 3 1Department of Respiratory Diseases, Xijing Hospital, 2Institute of Neurosciences of Chinese PLA, 3Department of Pathology, Facul;NF-kB expression in LPS induced acute lung injury in mice[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-02
7 LIN Yun Xin 1, ZHANG Bing Fang 2, QI Hao Wen 2, LI Zhi Chao 3, JIA Bing 3 1Department of Respiratory Diseases, 473 Hospital of Chinese PLA, Lanzhou 730070, China, 2Department of Respiratory Diseases, Xijng Hospital, 3Department;Influences of intravenous infusion of cardionatrin on TNF-α, IL-8 and ET-1 contents in blood and bronchio-alveolar lavage fluid of rabbits with acute lung injury induced by oleic acid[J];Journal of The Fourth Military Medical University;2001-15
8 ZHANG Bing Fang 1, LIN Yun Xin 1, QI Hao Wen 1, LI Zhi Chao 2, XUE Jun 1, JIA Bin 2, ZHAO Shu Hua 1 1Department of Respiratory Medicine, Xijing Hospital, 2Deparment of Pathophysiology, Faculty of Preclinical Medicine, Fourth Milit;Effects of calcitionin gene-related peptide on cytokines of rabbits with acute lung injury induced by oleic acid[J];Journal of The Fourth Military Medical University;2002-14
9 YAN Zhi-Qiang 1, LI Zhi-Chao 1, LI Zhi-Bin 1, SONG Jing-Chun 1, WEI Min 2 1Department of Pathophysiology, School of Basic Medicine, Fourth Military Medical University, Xi’an 710033, China, 2Clinic, Kashi Military Subregion in Xinjiang, Kashi 844200, China;Effect of atrial natriuretic peptide on acute lung injury and possible mechanism[J];Journal of The Fourth Military Medical University;2004-23
10 LIANG Shi-wei, CHEN Ye-mingDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;Effects of penehyclidine hydrochloride or atropine combined with neostigmine for antagonizing residual neuromuscular block on patient's hemodynamics[J];Journal of First Military Medical University;2005-12
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 QIAO Yan-Guo1, LIU Hui2, HAN Ying1, HUANG Zhi-Gang3 1First Department for Senior Officials, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China, 2Department of Internal Medicine, Hospital of NO.8640 Unit, Chinese People's Armed Police Forces,Dingzhou 073000,China, 3Department of Internal Medicine, PLA 305 Hospital, Beijing 100017, China;Dynamic changes of brain natriuretic peptide in heart failure with carvedilol[J];Journal of the Fourth Military Medical University;2006-03
2 WEI Xiao-Long,WEI Ji-Fu,HUANG Tian,CHEN Qiu-Yu,LIU Yue-Ning,HE Shao-Heng Research Institute of Allergy and Inflammation,Medical College,Shantou University,Shantou 515031,China;Acute lung injury induced by L-amino acid oxidase purified from Agkistrodon blomhoffii ussurensis venom[J];Journal of the Fourth Military Medical University;2006-22
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved