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Characteristics of high-risk osteosarcoma and treatment countermeasure

WANG Zhen 1, HUANG Yao Tian 1, HUANG Lu Yu 1, ZHAO Jin Kang 1, YU Hui Dong 1, LIU Ji Zhong 1, DU Xiao Chuan 2, LI Jing Bang 2, YAN Pei Song 3, WANG Zhi Xiang 4 1Institute of Orthopeadics of Chinese PLA, 2Department of Radi  
AIM We discussed the characteristics and treatment of high risk osteosarcoma by analyzing prognostic factor and survival rate of 61 osteosarcoma patients, and reported some experience. METHODS Depending on 61 osteosarcoma patients who undertook limb salvage operation and had integrity following up data, we adopted image analyzing technology to process the prognostic factors, which included absolute tumor length, width, depth, area and maximum transverse diameter. RESULTS 61 osteosarcoma cases had been followed up for 10 years. Five year survival rate was 57.5%. The high risk factors included III surgery stage, higher than 2/3 area ratio of sarcoma to host bone, more than 6 centimeters maximum transverse diameter, pathological fracture, and higher than 2/3 positive area per sight scope of PCNA in biopsy specimen. Then we undertook repeated pre operation chemotherapy, high selective artery embolism and chemotherapy, and salvage procedures for 16 high risk osteosarcoma patients, there were 2 death, 5 survival with tumor and 9 non tumor survival after 18 months following up, and the successful salvage rate was 68.7%. CONCLUSION Our research leads the active treatment to high risk osteosarcoma, aims directly at the osteosarcoma and provides comprehensive treatment project.
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