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《Journal of The Fourth Military Medical University》 2002-09
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Activity changes of cell signal transduction factors in apoptotic hepatoma SMMC-7721 cell induced by cisplatin

ZHENG Ren Hong 1, DOU Ke Feng 1, LIANG Ke Ming 2 1Department of Hepatobillary Surgery, 2Department of Radiation Therapy, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China  
AIM To investigate activity changes of cell signal transduction factors (JIN/SAPKs, p38MAPK, ERK, JUN, CREB) in apoptotic hepatoma SMMC 7721 cell induced by CDDP. METHODS Using immunocytochemistry and FCM methods. RESULTS After treatment with CDDP at 15 mg·L -1 , there were apoptotic peaks in cell cycle analysis on FCMfor 48 h and expression of MAPKs and transcripton factors in cell plasm and/or nucleus for 72 h. CONCLUSION MAPKs pathway and transcription factors (JUN, CREB) are concerned with apoptosis of hepatoma SMMC 7721 cell induced by cisplatin.
【CateGory Index】: R735.7
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9 ZHANG Xiao-Zhan, NAN Ke-Jun, RUAN Zhi-Ping, XU Rui, GUO Hui Department of Oncology, First Hospital, Xi'an Jiaotong University, Xi'an 710061, China;Clinical significance of p34~(cdc2) expression in hepatocellular carcinoma tissue[J];Journal of The Fourth Military Medical University;2005-01
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【Secondary References】
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1 Yan Wang,Qi Li,Zhong-Ze Fan,Jue Sun,Hong Gao,Department of Oncology,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China Yi-Qin Wang,School of Basic Medical Science,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China Rui-Hai Liu,Department of Food Science,Cornell University,Ithaca,New York 14853,USA;Tanshinone ⅡA induces apoptosis of liver cancer cells via p38MAPK signal transduction[J];World Chinese Journal of Digestology;2009-02
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