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《Journal of The Fourth Military Medical University》 2002-09
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Activity changes of cell signal transduction factors in apoptotic hepatoma SMMC-7721 cell induced by cisplatin

ZHENG Ren Hong 1, DOU Ke Feng 1, LIANG Ke Ming 2 1Department of Hepatobillary Surgery, 2Department of Radiation Therapy, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China  
AIM To investigate activity changes of cell signal transduction factors (JIN/SAPKs, p38MAPK, ERK, JUN, CREB) in apoptotic hepatoma SMMC 7721 cell induced by CDDP. METHODS Using immunocytochemistry and FCM methods. RESULTS After treatment with CDDP at 15 mg·L -1 , there were apoptotic peaks in cell cycle analysis on FCMfor 48 h and expression of MAPKs and transcripton factors in cell plasm and/or nucleus for 72 h. CONCLUSION MAPKs pathway and transcription factors (JUN, CREB) are concerned with apoptosis of hepatoma SMMC 7721 cell induced by cisplatin.
【CateGory Index】: R735.7
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【References】
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【Co-references】
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1 ZHOU Xu long 1, LI Di chen 2, CAO Guang qun 2 1. Department of Pathology, Medical College of Jinan University, Guangzhou 510632,P.R. China 2. Department of Pathology, Bengfu Medical College,Anhui,P.R. China;A study on the ectopic HCG and cyclic nucliotides in patients with primary lung cancer[J];CHINESE JOURNAL OF CANCER;2000-02
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3 XIA Bing 1 ,LU Jian 2 Department of Pathophysiology,The Second Military Medical University,Shanghai 200433,P.R.China;Rapid Inhibition of Extracellular Signal-Regulated Kinase 1/2in a Human Ovarian Cancer Cell Line by Dexamethasone[J];Chinese Journal of Cancer;2002-08
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10 ZHENG Lian-He1,ZHANG Wei2,HAN Tao1,MA Bao-An1,FAN Qin-Yu1 1Department of Orthopedics, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038,China, 2Department of Microbiology,School of Basic Medicine,Fourth Military Medical University, Xi'an 710033,China;Study on the molecular mechanisms of osteosarcoma cell apoptosis induced by Adriamycin[J];Journal of The Fourth Military Medical University;2005-12
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1 Yan Wang,Qi Li,Zhong-Ze Fan,Jue Sun,Hong Gao,Department of Oncology,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China Yi-Qin Wang,School of Basic Medical Science,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China Rui-Hai Liu,Department of Food Science,Cornell University,Ithaca,New York 14853,USA;Tanshinone ⅡA induces apoptosis of liver cancer cells via p38MAPK signal transduction[J];World Chinese Journal of Digestology;2009-02
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