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《Journal of The Fourth Military Medical University》 2002-15
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Study of therapeutic time window for Shenfu solution in transient focal cerebral ischemic injury in rats

ZHENG Yu, XIONG Li Ze, ZHU Zheng Hua, WANG Qiang, CHEN Shao Yang Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China  
AIM To investigate the therapeutic time window for Shenfu solution in transient focal cerebral ischemic injury in rats. METHODS 80 male SD rats weighing 280~350 g were randomized into 8 groups ( n =10 in each group): Control group, receiving no pharmacological intervention, Groups A~G, receiving intraperitoneal injection of Shenfu solution (10 mL·kg -1 ) at 0, 0.5, 1.0, 1.5, 2.0, 4.0 and 6.0 h respectively after 120 min middle cerebral artery occlusion (MCAO) with 3 0 nylon monofilament via the right internal carotid artery. The neurological outcomes were evaluated 24 h after the reperfusion. The brain infarct volumes were then assessed by TTC staining. RESULTS The neurological deficit scores (NDS) for Groups A~F 24 h after the reperfusion were 0.5±0.3, 0.5±0.4, 0.6±0.5, 0.8±0.4, 0.8 ±0.3 and 0.9±0.3, respectively, which were obviously lower than those of the control group (2.1±0.8) and Group G ( 1.5 ±0.7) ( P 0.05). The infarct volumes of the control group (182.6±39.6) mm 3 and Group G (139.1±42.8) mm 3 were significantly larger than those of Groups A~F ( 46.4 ±26.1), (60.2±25.8), (67.2±36.7), (76.0±39.7), (94.1±34.9) and (98.4±35.3) mm 3, respectively ( P 0.05) 24 h after the reperfusion. There were no differences between Groups A~F in both NDS and infarct volume ( P 0.05). CONCLUSION Therapeutic time window for Shenfu solution in transient focal cerebral ischemic injury lasts for at least 4 h.
【Fund】: 国家自然科学基金资助项目 (3 0 170 90 7)
【CateGory Index】: R285.5
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