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Research of the effect of ulinastatin on infection of rats with obstructive jaundice

FENG Quan Xin 1,DOU Ke Feng 1,LI Hai Min 1,ZHEN Shan Lan 2,SUN Yi Qun 2,PENG Dao Rong 2 1Department of Hepatobiliary Surgery, 2Clinical Laboratory,Xijing Hospital,Fourth Military Medical University,Xian 710033,China  
AIM:To study the effects of ulinastatin (UTI) on infection of rats with obstructive jaundice.METHODS: Eighty SD rats were assigned randomly into four groups: Control group (A), UTI group (B), prevent group (C) and pseudoperation group (D), and were sacrificed seven days late. A, B and C groups were operated on, the common bile-duct was ligated. UTI was given intraperitoneally at the dosage of 40 000 IU/kg/d in UTI group at the first day of postoperation and in prevent group at the previous day of preoperation. In the control and pseudoperation groups, 0.9 % NS was given intraperitoneally at the first day of postoperation. When the rats were sacrificed, their blood was taken for blood routine and germ culture A small part of the live was taken for light microscopic examination. RESULTS: The WBC levels of A, B, C and D groups were (19 4±2 4)×10 9 ·L -1 , (14 9±2 3)×10 9 ·L -1 , (11 0±2 7)×10 9 ·L -1 and (9 2±1 8)×10 9 ·L -1 , respectively, which were significantly different ( P 0 01). By light microscopic examination, the degeneration of hepatocytes and neutrophil infiltration in the liver in A, B and C groups was observed. The changes in A group was more obvious than those in the other groups and focal necrosis of hepatocytes and lobules damage were also observed. CONCLUSION: UTI has a significant preventive effects on the infection of rats with obstructive jaundice.
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