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《Journal of The Fourth Military Medical University》 2003-08
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Research of the effect of ulinastatin on infection of rats with obstructive jaundice

FENG Quan Xin 1,DOU Ke Feng 1,LI Hai Min 1,ZHEN Shan Lan 2,SUN Yi Qun 2,PENG Dao Rong 2 1Department of Hepatobiliary Surgery, 2Clinical Laboratory,Xijing Hospital,Fourth Military Medical University,Xian 710033,China  
AIM:To study the effects of ulinastatin (UTI) on infection of rats with obstructive jaundice.METHODS: Eighty SD rats were assigned randomly into four groups: Control group (A), UTI group (B), prevent group (C) and pseudoperation group (D), and were sacrificed seven days late. A, B and C groups were operated on, the common bile-duct was ligated. UTI was given intraperitoneally at the dosage of 40 000 IU/kg/d in UTI group at the first day of postoperation and in prevent group at the previous day of preoperation. In the control and pseudoperation groups, 0.9 % NS was given intraperitoneally at the first day of postoperation. When the rats were sacrificed, their blood was taken for blood routine and germ culture A small part of the live was taken for light microscopic examination. RESULTS: The WBC levels of A, B, C and D groups were (19 4±2 4)×10 9 ·L -1 , (14 9±2 3)×10 9 ·L -1 , (11 0±2 7)×10 9 ·L -1 and (9 2±1 8)×10 9 ·L -1 , respectively, which were significantly different ( P 0 01). By light microscopic examination, the degeneration of hepatocytes and neutrophil infiltration in the liver in A, B and C groups was observed. The changes in A group was more obvious than those in the other groups and focal necrosis of hepatocytes and lobules damage were also observed. CONCLUSION: UTI has a significant preventive effects on the infection of rats with obstructive jaundice.
【CateGory Index】: R657.3
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【References】
Chinese Journal Full-text Database 1 Hits
1 CHI Da Chao, HAN Xi Wang, YAN Li Kun, HE Wen Xian Department of General Surgery, Shaanxi Provincial People’s Hospital, Xi’an 710068, China;Effects of urinary trypsin inhibitor on postoperative immune function in patients with gastrointestinal cancer[J];Journal of The Fourth Military Medical University;2004-15
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 WANG Hao 1,WU Guo hao 1,ZHOU Zhao yan 2,LIU Jia 3 (1.Department of General Surgery; 2.Department of microorganism; 3.Department of pathology, Zhongshan Hospital,Fudan University,Shanghai 200032,China);The influences of different nutritional formulas and routes on the intestinal barrier in rats with gut ischemia/reperfusion injury[J];Parenteral & Enteral Nutrition;2004-01
2 XU Ren ying 1,CAO Wei xin 2,CHEN Xue hua 3,ZHANG Ming jun 3,ZHANG Yi 3 (1.Department of Clinical Nutrition,Shanghai Renji Hospital,Shanghai 200001,China;2.Department of Clinical Nutrition,Shanghai Ruijin Hospital,Shanghai 200025,China;3.Research Institute of Gastrointestinal Surgery,Shanghai Ruijin Hospital,Shanghai 200025,China);The effects of enteral nutrition on liver injury and albumin gene transcription in obstructive jaundice rats[J];Parenteral & Enteral Nutrition;2004-03
3 Wang yong,Hu zhiqian,Chen zhigang,Zhang lingzhen,Wang yuanhe,Department of General Surgery,Chang Zheng Hospital,Second Miliary Medical University.Shanghai 200003;EFFECT OF ASTRAGALUS ON CELLULAR IMMUNE FUNCTION OF RATS WITH OBSTRUCTIVE JAUNDICE[J];JOURNAL OF HEPATOBILIARY SURGERY;2000-01
4 Ji Fu,Sun Jianhua,Shi Weijing,et al.Department of General Surgery,Ren Ji Hospital,Shanhai Second Medical University(200001);Experiment of sodium dehydrocholate in treating the endotoxemia of obstructive jaundice.[J];JOURNAL OF HEPATOPANCREATOBILIARY SURPERY;1999-01
5 WANG Jun LI SHui-Qing JIANG Jian-Yu(The Third Hospital, Peiking Vniversity Beijing 100083);The Effects of Ulinastain on Immune Function and Renal Function During the Patients Undergoing Interfixation of Spine[J];The Chinese Journal of Clinical Pharmacology;2002-03
6 Peng Xiaohua( Department of Internal medicine, AnJi County Second people's Hospital, Anji County ZhengJiangprovinre 313300);The expression of transforming growth factor-β_1 in liver of obstructive jaundice and its significance[J];JOURNAL OF EMERGENOY MEDICINE;1999-01
7 JIN Jiansheng,ZHENG Xiangxiong,LIN Qingyou,et al Department of nephrology,Union Hospital,Fujian Medical University,Fuzhou (350001);Effect of Radix Astragali on sFasL and T Cell Subsets in Patients with Uremia[J];Chinese Journal of Integrated Traditional and Western Nephrology;2002-03
8 YANG Rong, GAO Jing (The Institute of Materia Medica, Nanjing University School of Medicine, Nanjing 210093);Progress in Gene Therapy of Liver Cirrhosis[J];Progress In Physiological Sciences;2004-01
9 Huang Wenguang 1, Zhang Peng 1, Shen Guanxin 2 Department of General Surgery,Xiehe Hospital,Tongji Medical University, Huazhong University of Science and Technology, Wuhan 430022 2 Department of Immunology, School of Basic Medical Sciences;Changes in Immune Function in the Patients with Gastric and Colorectal Cancer during the Perioperative Period[J];Acta Universitatis Medictnae Tangji;2001-04
10 TAN Jingwang,ZHANG Shaogeng,WANG Lei,et al.Department of Hepatobiliary Surgery,Fuzhou General Hospital PLA,Fuzhou(350025);Apoptosis as a Mechanism of Cell Death in the Liver of Obstructive J aundice.[J];Journal of Surgery Concepts & Practice;2003-02
【Secondary References】
Chinese Journal Full-text Database 6 Hits
1 WANG Yuan-sheng,YANG Xing,HUANG Man,et al(Department of Anesthesiology,Jiangmen Central Hospital,Jiangmen,Guangdong 529030,China);Ulinastatin's Protective Effects on Postoperative Liver and Renal Function of Elderly Patients Undergoing Radical Resection of Rectal Carcinoma[J];Journal of University of South China(Medical Edition);2009-02
2 SUN Yun-peng,YU Guan-feng,LIAO Yi,et al.(Department of General Surgery,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China);Clinical observation of ulinastatin's protective effects on postoperative liver and renal function of patients with gastric cancer[J];Journal of Clinical Surgery;2008-04
3 Duan Xiao-qin,Song De-biao,Zhao Yan,et al Intensive Care Unit,Second Hospital of Jilin University,Changchun 130041,China;Clinical effects of bundle therapy in treatment of multiple organ dysfunction syndrome[J];China Journal of Emergency Resuscitation and Disaster Medicine;2008-03
4 MIAO Hui-Lai,CHEN Nian-Ping,CHEN Ming,QIU Zhi-Dong,XU Hao(Department of Hepatobiliary Surgery,Hospital affiliated to Guangdong Medical College,Zhanjiang 524001,China);Effects of ulinastatin on chemotherapy after resection of hepatocellular carcinoma[J];Pharmaceutical Care and Research;2006-03
5 HUANG Shun-wei,GUAN Xiang-dong,CHEN Juan,OUYANG Bin.Department of SICU,First Affiliated Hospital of Sun-Yat Sen University,Guangzhou 510800,China;Immunomodulation therapy improves inflammatory cytokines,humoral immunity and cellular immunity in septic patients[J];Chinese Journal of Clinicians(Electronic Edition);2009-10
6 HUANG Shun-wei,GUAN Xiang-dong,CHEN Juan,OUYANG Bin,YANG Chun-hua,CHEN Min-ying(Surgical Intensive Care Unit,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China. );Effect of ulinastatin plus thymosin-α_1 therapy on improving immune function in septic patients[J];Chinese Journal of Pathophysiology;2009-11
China Proceedings of conference Full-text Database 1 Hits
1 HUANG Shun-wei,GUAN Xiang-dong,CHEN Juan,OUYANG Bin,YANG Chun-hua, CHEN Min-ying (Surgical Intensive Care Unit,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China.;Effect of ulinastatin plus thymosin-α_1 therapy on improving immune function in septic patients[A];[C];2009
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