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《Journal of The Fourth Military Medical University》 2004-01
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Relationship between apoptosis and expression of Caspase-3 after cerebral hemorrhage

ZHANG Yan Ling 1, CHEN Kang Ning 1, SHAO Shu Qin 1, WANG Ying 2 1Department of Neurology, Southwest Hospital, 2Department of Pathogenic Biology, College of Medicine, Third Military Medcial University, Chongqing 400038, China  
AIM: To explore the change of apoptosis around the hematoma after cerebral hemorrhage and relationship between apoptosis and expression of Caspase 3. METHODS: The intracerebral hemorrhage (ICH) rat model was made by intracranial injection of Ⅳ collagenase. Healthy male Wistar rats were divided into ICH and control groups in random. Collagenase/heparin in saline solution or pure saline solution was injected into the caudate nucleus. 6 h, 12 h, 24 h, 3 d and 7 d after the injection, We got the brain frozen sections. The sections were stained by TUNEL to find the apoptosis cell. The expression of Caspase 3 was observed by immunohistochemistry and in situ hybridization. The number of the positive cells were observed by the image analyzer. RESULTS: Some TUNEL positive cells were found around the hematoma 6 h after cerebral hemorrhage.The largest area with TUNEL positive cells occurred at 3 d after injection of collagenase/heparin in saline solution. The expression of Caspase 3 changed as the apoptosis. CONCLUSION: Apoptosis exists around the hematoma after cerebral hemorrhage. The expression of Caspase 3 changed as the apoptosis. The expression of Caspase 3 decide the level of apoptosis induced by ICH.
【CateGory Index】: R743.34
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