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《Journal of The Fourth Military Medical University》 2004-01
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Effect of continuous dynamic compressive stress on femoral fractures healing in dogs

REN Ke, ZHANG Chun Cai, XU Shuo Gui, TANG Hao, KANG Qing Lin, GAO Tang Cheng, ZHANG Xue Song Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China  
AIM: To explore the effect and mechanism of continuous dynamic pressure stress on femoral fractures healing in dogs. METHODS: Bilateral femoral of 15 adult dogs were osteotomized in the middle and then 1 femur was randomly internal fixed with swan like memory connector (SMC) while the contralateral side fixed with Kuntscher intramedullary nails. Five animals in each group were sacrificed at 7, 14, 21, 28, 49 d after operation. Samples from the fracture gaps were obtained and histological and molecular biological techniques (expression of the mRNA of the cartilage specific collagen IX and osteocalcina marker for mature osteoblasts) were employed. RESULTS: In terms of histology and molecular biology, the chondrogenesis in the fracture gap continued for shorter period and the enchondral ossificassion were strengthened in fractures fixed with SMC. CONCLUSION: The persistent dynamic longitudinal pressure stress produced by SMC may contribute to the process of healing of long bone.
【CateGory Index】: R683
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