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《Journal of The Fourth Military Medical University》 2005-04
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Association of polymorphisms of transforming growth factor-beta 1 gene with susceptibility to essential hypertension in Zhuang nationality of Guangxi province

WEI Ye-Sheng 1,LI Zhuang 1,LAN Jing-Sheng 2 1Clinical Laboratory Center, 2Department of Cardiovasology,Affiliated Hospital,Medical College for Youjiang Nationality,Baise 533000,China  
AIM: To study the relationship of the polymorphisms of transforming growth factor-beta 1 (TGF-β 1)gene+869T/C and +915G/C in the exon 1 with essential hypertension in population of Chinese Zhuang nationality.METHODS: The polymorphisms of TGF-β 1 gene were analyzed by sequence specific primers-polymerase chain reaction (PCR-SSP) methods in 172 patients with essential hypertension and 180 healthy controls.RESULTS: The TGF-β 1 gene +869T/C polymorphism was significantly different between the two populations.The relative risk of suffering from essential hypertension of T allele was 1.525 times that of C allele(OR =1.525,95% CI:1.133~2.053).The systolic blood pressure level of TGF-β 1 C allele carriers was significantly higher than that in non-carriers(22.0±3.9 kPa vs 21.1±3.1 kPa,P0.05).But the polymorphism distributions of TGF-β 1 gene +915G/C polymorphism was not different between the essential hypertension group and the control group.CONCLUSION: TGF-β 1 gene +869T/C polymorphism is associated with essential hypertension and C allele may be a risk factor for essential hypertension.The TGF-β 1 C allele carriers may have increased risk of essential hypertension by enhancing the systolic blood pressure.
【CateGory Index】: R544.1
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