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《Journal of the Fourth Military Medical University》 2006-05
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Effect of NF-κB,Bcl-2 and Bax on neuronal apoptosis in experimental presyrinx state

SUN Guo-Zhu~1, ZHANG Qing-Jun~2, ZHANG Geng-Shen~1, LI Jian-Feng~1~1Department of Neurosurgery, Second Hospital, Hebei Medical University, Shijiazhuang 050000, China, ~2Department of Neurosurgery, People's Hospital, Peking University, Beijing 100044, China  
AIM: To investigate neuronal apoptosis in experimental presyrinx state and the regulatory role and mechanism of NF-κB, Bcl-2 and Bax in rabbits. METHODS: The experimental syringomyelia models of rabbits were established by intra- cisternal injection of Kaolin. Neuronal apoptosis and the expressions of NF-κB, IκB, Bcl-2 and Bax were measured with TUNEL and immunohistochemistry in 1, 3, 7, 14 and 21 d after operation respectively . RESULTS: Compared with that in control group, the NF-κB expression in Kaolin group increased from the 1st day after operation, reached its peak at 3rd day, remained there till 7th day, and returned to a normal level at 14th day approximately. The IκB expression showed a negative correlation with NF-κB at the same time points. The Bcl-2 and Bax expressions increased from the 1st day, reached its peak at 7th day, remained there till 14th day, and then began to drop. CONCLUSION: In presyrinx state of experimental syringomyelia, the increasing expression of NF-κB mainly upregulates its target gene Bax, thus inducing neuronal apoptosis to involve in nervous function injury.
【Fund】: 河北省科技厅基金(002761100)
【CateGory Index】: R744
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【References】
Chinese Journal Full-text Database 2 Hits
1 SUN Guozhu1,LI Zhaohui1,ZHANG Qingjun2,ZHAO Zongmao1,ZHANG Gengshen11Department of Neurosurgery,The 2 nd Hospital of Hebei Medical University,Shijiazhuang 050000;2Department of Neurosurgery,People's Hospital of Peking University,Beijing 100044,China;Effect of protein kinase C on expression of NF-κB and IκB in experimental presyrinx state[J];Chinese Journal of Neurosurgical Disease Research;2008-03
2 LI Xiu-Shan,SUN Guo-Zhu,GAO Xiao-Wei,et al.Department of Neurosurgery,People′s Hospital of Guantao County,Handan 057750,Hebei,China;Effect of PKC on neuronal apoptosis regulated by Bcl-2 and Bax in experimental presyrinx state[J];Chinese Journal of Gerontology;2011-21
【Citations】
Chinese Journal Full-text Database 3 Hits
1 LI Wen Lian, WANG Ling, ZHANG Hong Ai Department of Paediatrics, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China;Influence of Ca~(2+) on the phosphorylation of CREB, and the relationship between P-CREB and apoptotic neurons in neonatal rats after hypoxic-ischemia[J];Journal of The Fourth Military Medical University;2004-03
2 MA Li-Jie~1,WANG Hong~2,WANG Xiang-Li~1,LIU Ying-Jie~1,WANG Ping~21Department of Orthopedics,Affiliated Hospital,~2Department of Foreign Language,North China Coal Medical College,Tangshan 06300,China;Relationship between cell apoptosis and Bcl-2/Bax ratio in neural cells after acute spinal cord injury in rats[J];Journal of The Fourth Military Medical University;2005-22
3 ZHANG Qingjun, SHUN Guozhu, ZHANG Gengshen, et al. Department of Neurosurgery, 2nd Hospital of Hebei Medical University, Shijiazhuang,050000;Comparison of serial MRI studies and histological findings of experimental syringomyelia in rabbits[J];Chinese Journal of Neurosurgery;2000-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 SUN Guo-zhu1,ZHANG Qing-jun2△,WANG Hao1(1.Department of Neurosurgery,The 2nd Hospital of Hebei Medical University,Shijiazhuang 050000,China;2.Department of Neurosurgery,Peking University People's Hospital,Beijing 100044,China);Expression of aquaporin 4 during development of experimential presyrinx state in rabbits[J];Journal of Peking University(Health Sciences);2007-02
2 SI Dao-Wen1,ZHOU Hong-Xia1,ZHANG Yu-Xin1,CHENG Ai-Guo2,ZHANG Zuo-Feng11Department of Anatomy,School of Basic Medicine,2Department of Orthopaedics,Affiliated Hospital,North China Coal Medical College,Tangshan 063000,China;Neuroprotective effect of progesterone on neurons after traumatic brain injury in rats and its mechanism[J];Journal of the Fourth Military Medical University;2007-17
3 YANG Guo-feng1, WANG Lu-ning1, YANG Li-bin2, ZHANG Qing-jun3Departments of Geriatric Neurology1 and Neurosurgery2, General Hospital of PLA, Beijing 100853, China; 3Department of Neurosurgery, Hebei Medical University, Shijiazhuang 050071, China;Effect of Ginkgo biloba extract on neuronal apoptosis in rabbit with kaolin-induced syringomyelia[J];Journal of First Military Medical University;2005-01
4 SUN Guo-zhu1,HU Qing-shan2,ZHANG Qing-jun3,ZHAO Zong-mao1,ZHANG Geng-shen1 1Department of Neurosurgery,Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;2Department of Surgery,Traditional Chinese Medicine Hospital of Lingshou County,Shijiazhuang 050500,China;3Department of Neurosurgery,People's Hospital of Peking University,Beijing 100044,China;Changes of protein kinase C activity in experimental presyrinx state in rabbits[J];Journal of Southern Medical University;2008-04
5 Pei Shaobao,Fang Jian,Wu Jian,et al.Department of Spine Surgery,the First People's Hospital of Hefei,Hefei,230003;Expression of Bcl-2 and Bax Gene and Comparison with Apoptosis Detected by TUNEL in Early Stage of Spinal Cord Blast Injury in Rabbits[J];Chinese Journal of Bone and Joint Injury;2011-11
6 WANG Kun-peng;TANG Ru-rong;BAI Tao;BAI Yu;Department of Neurosurgery,The First Hospital,China Medical University;;The effect of γ-secretase inhibitor on the expression of CREB in hippocampus of cerebral ischemia-reperfusion mice[J];Anatomy Research;2013-05
7 WANG Hai-feng,FANG jian,PEI Shao-bao,et al. (Department of orthopedics,the PLA clinical faculty of Anhui Medical University,the PLA 105 Hos- pital,Hefei 230031,China);The expression and significance of Bcl-2 and Bax proteins in the early stage of the spinal cord blast injury in rabbit[J];The Journal of Cervicodynia and Lumbodynia;2010-02
8 ;NF-κB、IκB、GFAP在脊髓空洞前状态中的表达和作用[J];Journal of Brain and Nervous Diseases;2004-04
9 SUN Guo-zhu, LI Jianfeng, ZHANG Qingjun,et al. Department of Neurosurgety, The 2nd Hospital of HeBei Medical University, 215 Heping West Road, Shijiazhuang 050000;A study on death models of nervous cells in experimental presyrinx state[J];Journal of Brain and Nervous Diseases;2007-01
10 SUN Guo-zhu, Li Jian-feng, ZHANG Qing-jun,et al. Department of Neurosurgery, The 2nd Hospital of HeBei Medical University, Shijiazhuang 050000, China;Effects of PKC on spinal edema in experimental presyrinx state in rabbits[J];Journal of Brain and Nervous Diseases;2007-05
【Co-references】
Chinese Journal Full-text Database 6 Hits
1 Chen Kangning, Dong Weiwei (Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing, 400038);Changes of activity of protein kinase C during cerebral ischemia/reperfusion in rats[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;1998-05
2 陈康宁;A PRELIMINARY STUDY ON THE RELATIONSHIP BETWEEN SERUM INTERLEUKIN-6 AND ACUTE CEREBRAL INFARCTION[J];;1996-04
3 Li Yunfeng,Chen Kangning,Zheng Caimei. Department of Neurology, Jinan Military Gene ral Hospital, Jinan 250031;PKC activity,FOS and BCL-2 expression after cerebral ischemia reperfusion in rats[J];JOURNAL OF CLINICAL NEUROLOGY;2000-01
4 LUO Wei 1, ZHAO Kuanyan 2, WANG Tinghua 2 1Department of Neurosurgery, First Hospital of Zhuzhou, Zhuzhou 412000; 2Institute for Research of Neuroscience,Kunming Medical College, Kunming 650031, China;The changes in the expression of bFGF,GDNF in neurons following hemisection of spinal cord injury[J];Chinese Journal of Neurosurgical Disease Research;2005-02
5 ZHANG Qingjun, SHUN Guozhu, ZHANG Gengshen, et al. Department of Neurosurgery, 2nd Hospital of Hebei Medical University, Shijiazhuang,050000;Comparison of serial MRI studies and histological findings of experimental syringomyelia in rabbits[J];Chinese Journal of Neurosurgery;2000-06
6 SUN Guo-zhu ,ZHANG Qing-jun ,LI Jian-feng ,et al. Department of Neurosurgery, The 2nd Hospital of Hebei Medical University, Shijiazhuang 050000, China;Development of experimental presyrinx state and its guiding implications[J];Chinese Journal of Experimental Surgery;2006-12
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 Guang-Li REN, Ling WANG, Bao-Xi WANG, Yang WANG, Ying LIU, Mao-Gui WANG, Yan-Ping HUI Department of Pediatrics, Tangdu Hospital, Fourth Military Medical University, Xi' an 710038, China; De-partment of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China; Depart-ment of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China;Changes of p-CREB and c-fos Expression in the Hippocampus of Neonatal Rats after Hypoxic-Ischemic and Reperfusion Brain Damage[J];The Chinese Journal of Contemporary Pediatrics;2003-01
2 KANG JinChao, LIU WeiYong, CAI ZhenJie, LI Tong Center of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Expression of oncogene c-fos, c-myc in SD rat immature myocardium during hypoxia/reoxygenation[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-05
3 CHEN Yi Jun, ZHANG Xiang, FEI Zhou, GU Jian Wen, LIU Wei Ping Institute of Neurosurgery of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Apoptosis in human brain gliomas with different grades of malignancy[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-09
4 REN Guang Li 1, WANG Ling 1, WANG Bao Xi 1, HUI Yan Ping 2, LIU Ying 3, YAO Zhi Yong 3, WANG Mao Gui 1 1Department of Pediatrics, Tangdu Hospital, Fourth Military Medical University, Xian 710038, China, 2Department of Pathology, 3Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xian 710033, China;Neuron protection and expression of c-Jun and c-Fos in neonatal rats after hypoxic-ischemia brain damage and reperfusion[J];Journal of The Fourth Military Medical University;2003-04
5 WANG Xian Hui 1, LIANG Mi Fang 2, LI De xin 2, Xu Jing 1, MI Li 1, CHEN Zhi Nan 1 1Cell Engineering Research Centre, Fourth Military Medical University, Xian 710033, China, 2Institute of Virology, Chinese Academy of Preventive Medicine;Expression of murine bcl-X_L gene in CHO cells[J];Journal of The Fourth Military Medical University;2003-24
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