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《Journal of the Fourth Military Medical University》 2007-05
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Preventive and therapeutical effect of the kernel of zanthoxylum seed oil on experimental hyperlipidemia in rats

LIU Yong-Ying1,2, WANG Duo-Ning3, LIU Yuan-Sheng1,YANG Ying3,ZHAO Yan-Wu4,WANG Zeng-Lu5, YANG Ji-Qing11Department of Physics, School of Biomedical Engineering, Fourth Military Medical University, Xi'an 710033, China, 2Xi'an Yanliang 630 Hospital, Xi'an 710089, China, 3Scientific Research Center, Xi'an Medical College, Xi'an 710068, China, 4Economical Department, Engineering College of Armed Police Force, Xi'an 710086, China, 5Center for Biotechnology, Fourth Military Medical University, Xi'an 710033, China  
AIM: To investigate the effect of the kernel of zanthoxylum seed oil (KZSO) on experimental hyperlipidemia in rats and to probe into the mechanism of preventive and therapeutical effect of KZSO. METHODS: Thirty healthy SD rats were randomly divided into 3 groups, including control group, hyperlipidemia model group and KZSO group. Control group was fed ordinary forage; model group was fed high-lipid forage; KZSO group was administrated intragastrically KZSO besides high-lipid forage. Blood samples were obtained by cutting necks after 10-week feeding. The levels of blood lipids and the hemorheological parameters were determined, and the activities of superoxide dismutase (SOD) and catalase (CAT), the content of malondialdehyde (MDA) and the restraining ability to hydroxyl free radical (RAHFR) in the liver tissues were measured. RESULTS: Compared with the model group, cholesterol, triglyceride, high blood viscosity,and low blood viscosity of the KZSO group were decreased (P0.05, P0.01), high-density lipoprotein cholesterol was increased (P0.05). The activities of SOD and CAT and the RAHFR in the liver tissues of KZSO group were increased (P0.05, P0.01) and the content of MDA was decreased (P0.05) as compared with the model group. CONCLUSION: KZSO can modulate the blood lipid, improve the indexes in hemorheology and prevent lipid hyperoxidation. The mechanism may be related to its componential effects.
【CateGory Index】: R285.5
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