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《Journal of the Fourth Military Medical University》 2007-12
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Hemostatic effect and histocompatibility of chitosan-human-like collagen on rabbit liver wound surface

MA Mao, FAN Dai-DiDepartment of Chemical Engineering, Northwest University, Xi'an 710069, China  
AIM: To investigate the hemostatic effect and histocompatibility of chitosan-human-like collagen on rabbit liver wound surface. METHODS: New Zealand white rabbits were randomly divided into 3 groups: chitosan-human-like collagen group, human-like collagen group and gelatin sponge group. 1cm×1cm wound area was made on the surface of the liver of rabbits. Chitosan-human-like collagen, human-like collagen and gelatin sponges were respectively used on the wound surface. Bleeding time and histocompatibility were evaluated. RESULTS: Bleeding time of Chitosan-human-like collagen, human-like collagen and gelatin sponge groups were(78±11)s, (81±10) s and (115±13) s, respectively. Chitosan-human-like collagen group got the shorter bleeding time, which was obviously different from gelatin sponge group (P0.05). Histocompatibility of chitosan-human-like collagen group was obviously different from gelatin sponge group, and the former was superior to the latter. CONCLUSION: Added with chitosan, human-like collagen doesn't change in hemostatic effect and histocompatibility, however, its mechanical strength and ductibility are increased.
【CateGory Index】: R318.08
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