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《Journal of the Fourth Military Medical University》 2007-19
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Effect and mechanism of protection from hyperoxia-induced lung injury in new-born rats by SB203580

LUO Li-Man1, SUN Zhi-Qiang2, YU Jian1, NIE Guo-Ming1, LIU Jing1, ZOU Min-Shu11Department of Paediatrics, 2Department of Radiology, Wuhan General Hospital, Guangzhou Military Command, Wuhan 430070, China  
AIM:To investigate the mechanism of protection from hyperoxia-induced lung injury in new-born rats by SB203580, a p38MAPK specific inhibitor. METHODS: A total of 160 new-born rats were divided into air control group, hypero-xia-induced lung injury group, hyperoxia-induced lung injury + SB203580 group and hyperoxia-induced lung injury + sodium chloride group randomly. At the time points of 12, 24, 72 h and 1week, rats were executed, respectively. Left lungs at the time point of 72 h were availed to detect the expression of p38MAPK by Western Blot, and right lungs at the 4th time point were availed to detect the concentrations of IL-8 and TGF-β1 by ELISA. RESULTS: At the time point of 72 h, p38MAPK was expressed positively in hyperoxia-induced lung injury group and hyperoxia-induced lung injury + sodium chloride group;in the two groups, the concentrations of IL-8 and TGF-β1 increased significantly with time going on. And at each time point, their concentrations were higher than those in the air control group and hyperoxia-induced lung injury + SB203580 group (P0.01). CONCLUSION: Hyperoxia-induced lung injury in new-born rats can be relieved by the treatment of SB203580 through blocking the expressions of p38MAPK, then inhibiting the expression of IL-8 and TGF-β1.
【CateGory Index】: R563
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