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《Journal of the Fourth Military Medical University》 2008-03
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Expression of MMP-9 and its clinical significance in cervical squamous carcinoma

KONG Ling-Ling,WANG Xue-Chun,CUI Wen,WANG Xu,YANG Qing-Yuan,SONG Xi-Yuan,JIANG Xiao-Gang,YAN Chun-Yan Department of Pathology,Jining Medical College,Jining 272013,China  
AIM:To investigate the relationship of the expression of matrix metalloproteinase-9(MMP-9)with tumorigenesis,development and metastasis of cervical squamous carcinoma.METHODS:The expression and distribution of MMP-9 protein were detected by immunohistochemical SP method.The active protein and mRNA of MMP-9 were determined by gelatin Zymography and RT-PCR,respectively.The relationships between those indexes and the factors related to clinical pathology of cervical carcinoma were analyzed statistically.RESULTS:Immunohistochemical studies demonstrated that MMP-9 was expressed in 69.8% of squamous cell carcinomas(SCC)and 47.6% of high-grade squamous intraepithelial lesions(HSIL),but was less frequently expressed in low-grade squamous intraepithelial lesions(LSIL)(10%).In SCC,MMP-9 protein was expressed in 78.3% of patients with lymph node metastasis,and it was significantly higher than that in non-metastasis group(63.3%,P0.05).And the expression of MMP-9 was not significantly related to the pathological grade and clinical stage.By direct analysis of enzyme activities we found that the gelatinolytic activity of MMP-9 was significantly higher in SCC and HSIL than that in LSIL(P0.01).Expression of MMP-9 mRNA was also higher in SCC and HSIL than that in LSIL.CONCLUSION:MMP-9 is related well to the initial invasion and metastasis of cervical squamous carci-noma.The positive expression of MMP-9 can be used to indicate the metastatic potential and help clinicians to make therapeutic strategies.
【Fund】: 山东省济宁市科技局资助课题(2004JH011);; 山东省重点实验室资助项目(2005003)
【CateGory Index】: R737.33
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【References】
Chinese Journal Full-text Database 1 Hits
1 ZHU Feng1,ZHANG Yan2,ZHANG Hui-qing1,ZHANG Ying-jie1(1.Department of Urology,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100;2.Function Laboratory,Science and Technology Agency of Xinxiang Medical University,Xinxiang 453001,China);Correlations of matrix metalloproteinase content with invasion and metastasis of the transitional cell carcinoma of bladder[J];Journal of Modern Urology;2009-06
【Co-references】
Chinese Journal Full-text Database 1 Hits
1 Xue Hongpeng, Lu Yixia, Heilongjiang Provincial Hospital for Digestive Diseases, Ha'erbing, 150000 Zhou Zhaohai, The First Hospital of Mudanjiang, Heilongjiang Province, 157000;The Correlation between MMP-2 expression and Gastric Cancer Invasion and Metastasis[J];Chinese Medical Record;2008-01
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