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《Journal of the Fourth Military Medical University》 2008-03
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Short-term efficacy of super gamma knife radiation therapy for 56 patients with primary hepatic carcinoma

DANG Ya-Zheng1,YANG Jie2,WU Fa-Wei1,LEI Xu-Hu1,LU Wan-Ling1,ZHANG Peng1 1Cancer Center,PLA 323 Hospital,Xi'an 710054,China,2PLA First Hospital,Lanzhou 730000,China  
AIM:To evaluate the shot-term efficacy and safety of super gamma knife stereotaxic radiation therapy(SRT)for primary hepatic carcinoma(PHC).METHODS:Fifty-six PHC patients diagnosed via liver biopsy and histological examination were treated by SRT,and then observed for their short-term effects and side effects.Treatment Planning was 3 to 10 dots,3-6 Gy per-fraction,2-5 times per week,and the total treatment doses was 30-50 Gy.≥50% isodose covered planning target volume(PTV).Average dose on liver was less than 25 Gy and V30 Gy(volume percentage of normal liver receiving≥30 Gy dose)was less than 30%.RESULTS:In 56 patients with PHC including 24 patients with cancer emboli in portal vein,the complete remission(CR)rate was 17.9%(10/56),and the partial remission(PR)rate was 53.6%(30/56).The mean survival time was 10.6 months,and the 6-month survival rate was 96.4%(54/56).The side effect rate was 94.3%,and the digestive tract response rate was 92.8%(52/56).CONCLUSION:Technique of super gamma knife can effectively and safely control the progression of PHC and promote the survival rates of the patients.
【CateGory Index】: R735.7
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