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《Journal of the Fourth Military Medical University》 2008-06
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Preventive and therapeutical effect of Apple seed oil on experimental hyperlipidemia in rats

ZHAO Yan-Wu1,2,QIU Nong-Xue1,GAO Xia1,WANG Duoning3,YANG Ying3 1 College of Life Sciences,Shaanxi Normal University,Xi'an 710062,2Economical Department,Engineering College of People's Armed Police Forces,Xi'an 710086,3Scientific Research Center,Xi'an Medical University,Xi'an 710068,China  
AIM:To investigate the effects of apple seed oil(ASO)on the serum lipids,the aortic tectology and the activity of antioxidation in liver tissues of the hyperlipemia model rats.METHODS:Fifty healthy SD rats were randomly divided into 5 groups(10 rats per group),including control group,hyperlipidemia model group,Mix oil group(2.5 mL/kg BW)and two apple seed oil(ASO)groups:small dosage of ASO group(0.5 mL/kg/kgBW),large dosage of ASO(2.5 mL/kg.BW)group.Control group was fed ordinary forage;model group was fed high-lipid forage,the other groups were garaged by oils besides lipid forage.Blood samples were obtained by cutting necks after ten weeks feeding.After 10-week feeding,the levels of serum lipids were determined;aortic histomorphological changes were observed by the pathological section with the HE staining;the activities of superoxide dismutase(SOD)and catalase(CAT),and the restraining ability to hydroxyl free radical(OH)in the liver tissues were measured.RESULTS:ASO could restrain OH(P0.01)and enhance the activities of SOD(P0.01 or P0.05).ASO group had tendencies to decrease cholesterol and to increase high-density lipoprotein cholesterol,but there was no significance in statistics(P0.05).CONCLUSION:ASO had tendencies to decrease blood-lipids.and has the activity of antioxidation.
【Fund】: 农业部948项目“优质出口苹果生产和加工技术引进与示范”(2006-G28)
【CateGory Index】: R285.5
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