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《Journal of the Fourth Military Medical University》 2008-07
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Effect of heme oxygenase-1 on neuro-degeneration induced by aluminum overloading

YUAN Ye,GUO Jian-Zeng,YANG Jun-Qing,ZHOU Qi-XinDepartment of Pharmacology,College of Pharmacy,Chongqing Medical University,Chongqing 400016,China  
AIM: To investigate the effect of heme oxygenase-1(HO-1) on neurodegeneration induced by aluminum overloading(AO).METHODS: Seventy-five male NIH mice weighing 24-26 g were divided into control,aluminum chloride low dosage group(3.75 mg/d,LD) and high dosage group(7.50 mg/d,HD),which were intracerebraventricularly injected with 3 μL per mouse of artificial cerebrospinal fluid,1.25 g/L aluminum chloride solution and 2.50 g/L aluminum chloride solution,respectively once a day for 5 d to build the neurodegenerative model.The effect of HO-1 on neurodegeneration induced by AO was eva-luated by parameters including HO activity,HO-1 expression,content of malonaldehyde(MDA),levels of metal ions,and pathomorphological changes of hippocampi.RESULTS: The layer of CA1 pyramidal cells in both AO groups became thinner with pyknotic nuclei than control.The significant increases of HO-1 expression(LD 0.24±0.01,HD 0.33±0.01) and level of iron [(LD(31.34±2.85) mg/g,HD(54.01±2.31) mg/g)] with elevation of MDA level,HO activity and aluminum level were observed in both AO groups,compared with control group [HO-1 0.10±0.01,iron(22.54±4.48) mg/g,P0.05].CONCLUSION: Neurodegeneration induced by AO may involve in the up-regulation of HO-1,which raises the level of iron from degradation of the heme.
【Fund】: 国家自然科学基金(30672211)
【CateGory Index】: R363
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【References】
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1 DAI Xian-Kun1,WAN Jing-Yuan1,ZHANG Li2,GONG Xia3,NI An-Hong4,ZHOU Qi-Xin1 1Department of Pharmacology,2Department of Pathophysiolosy,3Department of Anatomy,Chongqing Medical University,Chongqing 400016,China,4Department of Dermatovenereology,Liyuan Hospital,Huazhong University of Sciences and Technology,Wuhan 430030,China;Effects and mechanism of lipoxin on LPS-induced inflammatory mediators in RAW264.7 macrophages[J];Journal of the Fourth Military Medical University;2009-14
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1 YU Gang~(1), WANG Li~(2), PENG Guo-guang~(1), DONG Wei-wei~(1) (~(1)Department of Neurology, The First Affiliated Hospital, ~(2)Department of Pathology, Chongqing University of Medical Sciences, Chongqing 400016, China);Neuroprotective effect of heme oxygenase-1 induced by hemin in the brain of rats suffered from ischemia-reperfusion injury[J];Acta Academiae Medicinae Militaris Tertiae;2005-17
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1 WANG Li1,YU Gang2,Xiang De-bing3,et al.(1.Department of Medical Oncology,Chongqing Cancer Institute,Chongqing 400030,China;2.Department of Neurology,First Affiliated Hospital of Chongqing University of Medical Sciences,400016,China;3.Department of Pathology,Daping Hospital and Research Institute of Surgery,Third Military Medical University,Chongqing 400042,China);Effect of hemin on expression of heme oxygenase-1 in hippocampal organotypic tissue cultures after combined oxygen/glucose deprivation[J];Chongqing Medicine;2008-24
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1 YANG Jun qing,ZHOU Qi xin (Department of Biochemical Pharmacology,Chongqing University of Medical Sciences,Chongqing 400016 China);Preventive Effects of Nimodipine on Cerebral Injury Induced by Carbon Monoxide Intoxication in Mice[J];Industrial Health and Occupational Diseases;2001-01
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