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《Journal of the Fourth Military Medical University》 2008-18
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Molecule of Chinese hebral drugs and molecular chinese herbal drugs

Si-wang WANG Institute of Materia Medica, School of Pharmacy,Fourth Military Medical University, Xi'an 7l0033, China  
AIM:To propose new proposition of constitute prescription by disease's morbidity character and the active component from molecule of chinese herbal drugs (MCHD) and molecular chinese herbal drugs (CHD) and to expound the new concepts of the "Molecular Composition Theory of CHD and the essentiality and significance of developing the modern Traditional Chinese Medicine(TCM). METHODS: By reviewing literature and data and summarizing experiences of our scientific research,we overviewed the forte and demerit of Theory of Traditional Chinese Medicine,analyzed the causes, and proposed new dieas for solving the demerit. RESULTS: ①CHD treated diseases with compound recipe of poly-ingredient. Praeparatum of CHD was generally prepareed with water decoction and alcohol extract. CHD had multitarget characteristic in clinic. ②Because of the unclear constituents and mechanism,praeparatum with"coarse,large and black", the popularization and international competition of CHD were severely depressed. ③The active component of CHD was the basis of its clinical curative effect,so we approved the viewpoint that the active component or effective part of CHD was named MCHD. We proposed the cocept of constitute prescription by disease's morbidity character and the active component from MCHD according to principle for determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs in Chinese medical sciences. The MCHD were categorized into principal drug, ministerial drug,adjuvant and messenger drug. We also aduanced a concept of "Molecular CHD". CONCLUSION: To inherit and develop the dominance of CHD theory, modern CHD theory system is gradually advocated. We would strive to advocate poly-sciences collaboration and to develop molecular CHD with definite active components and mechanism to achieve the international popularization of CHD.
【CateGory Index】: R28
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