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《Journal of the Fourth Military Medical University》 2009-14
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Effects of total ginsenoside combined with berberine on cardiac myosin heavy chain in experimental rats with chronic congestive heart failure

LI Yong-Min1,CHEN Xiao-Chun2,LUO Fei1,LI Gang1 1Section of Chinese Medicine and Recipe,Department of Traditional Chinese Medicine,2Department of Neurology,First Affiliated Hospital,Hebei North University,Zhangjiakou 075029,China  
AIM: To study the effects of total ginsenoside(GS)combined with berberine(Ber)on the expression of cardiac myosin heavy chain in cardiac cells of chronic congestive heart failure rats.METHODS: Animal models of heart failure were induced by subcutaneous injection of a large dose of ISO(80 mg/kg) for 12 d and were randomly divided into model group,GS+Ber group,captopril group and shenmai injection group.Some other rats served as control group.GS+Ber group were treated with total ginsenoside and berberine(each 20 mg/kg;once per day)by gavage,captopril group were given captopril(45 mg/kg;once per day)by gavage,shenmai injection group were injected intraperitoneally with shenmai injection(5 mL/kg;once per day)and model group and control group were given distilled water by gavage.After 4 weeks,hemodynamic indexes and cardiac weight index were examined and α-MHC and β-MHC mRNA expressions were detected by real-time quantitative PCR.RESULTS: LVSP,+dp/dtmax,-dp/dtmax and α-MHC mRNA expressions were lower and LVEDP,cardiac weight index and β-MHC mRNA expressions were significantly higher in control group than those in other groups(P0.01).Compared with those in model group,LVSP,+dp/dtmax,-dp/dtmax and α-MHC mRNA expressions were higher and LVEDP,cardiac weight index and β-MHC mRNA expressions were significantly lower in GS+Ber group and captopril group(P0.01 or P0.05).CONCLUSION: Total ginsenoside combined with berberine can increase α-MHC mRNA expression but decrease β-MHC mRNA expression in cardiac cells of chronic congestive heart failure rats,which may be one of the major mechanisms of improving heart function and ventricular remodeling.
【Fund】: 河北省科技支撑计划(08276101D-65)
【CateGory Index】: R285.5
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