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《JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY》 1996-05
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Experimental study on effects of NO on hepatic injury of rats with obstructive jaundice

Liu Peng 1, Li Kaizong 1, Fu Youchi 1, Wang Jicun 2, Zhou Qun 1, Wang Boyun 3 1Department of Hepatobiliary Surgery, 2Department of Digestive Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710033 3Department of Pathol  
Objective: To investigate the effects of nitric oxide (NO) on hepatic injury of rats with obstructive jaundice. Methods: Rats were injected intraperitoneally with L Arginine [300 mg/(kg·d)] or L N G nitroarginine methyl ester (L NAME) [70 mg/(kg·d)] for 7 d after bile duct ligation (BDL). The levels of NO - 2, MDA in the liver and serum transaminase were measured. The morphological changes in the liver were also observed. Results: The levels of NO - 2 and MDA in the liver were elevated at 7 d after BDL. In BDL rats treated with L Arginine, the level of NO - 2 in the liver increased significantly, whereas the levels of MDA in the liver and serum transaminase decreased compared with those of BDL rats ( P 0.05) and the liver injury was lessened; In BDL rats treated with L NAME, the level of NO - 2 in the liver decreased, but the MDA level and serum transaminase activities increased compared with those of BDL rats ( P 0.01), and the liver injury was aggravated. Conclusion: NO may play a protective role in liver injury resulted from obstructive jaundice.
【CateGory Index】: R657.4
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【Co-references】
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1 Ying Lei Cao Wei-xin (Department of Clinic Nutrition,Ruijin Hospital,Shanghai Second Medical University,Shanghai200025,China);Effects of Parenteral Nutrition on Albumin Transcription of Obstructive Jaundice Rat Liver[J];中国临床营养杂志;2002-01
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