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《JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY》 1999-06
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Effects of tangufican maxim polysaccharides in acute liver injury of mice

LIU Li1, LI BaoLi2, ZHOU SiYuan1, MEI QiBing1, ZHAO DeHua1, CAO ZhiXian3 1Department of Pharmacology, Faculty of Preclinical Medicine, Fourth Military Medical University, Xi'an 710033, Shaanxi Province, China, 2Yanan Medical College, 3Department of Pha  
AIM: To investigate the effects of TMP on acute liver injury in mice and to study the protective mechanism of TMP in mice with acute liver injury. METHODS: Three acute liver injury models of mice were made by using CCl4 (156 mg/kg), DGalN (800 mg/kg) and TAA (550 mg/kg) ip respectively, following TMP 100 mg/kg, 200 mg/kg and 400 mg/kg ig for 5 days respectively. RESULTS: The increasing trend of AST and ALT in serum and MDA in liver tissue was significantly inhibited. CONCLUSION: TMP can protect mice against CCl4, DGalN or TAAinduced acute liver injury.
【CateGory Index】: R965.4
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