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《Freshwater Fisheries》 2009-01
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Pharmacokinetics of Oxytetracycline in Hybrid Tilapia(Oreochromis aureus×O.niloticus)

YU Xiang-man1,ZHANG Qi-zhong1,YE Bo-xi1,Chen Guo-quan2,Gan An-hui2,ZHU Ze-yao1 (1.Institute of Hydrobiology,Jinan University,Guangzhou 510632;2.Agrotechnical Popularization Center of Baiyun District in Guangzhou 510405)  
Hybrid tilapia(Oreochromis aureus×O.niloticus)was treated orally with either oxytetracycline(OTC)aqueous solution or its medicated feed in a single dose of 50 mg/kg body weight at water temperature of(21±1)℃.The OTC concentrations of hybrid tilapia plasma were determined by high performance liquid chromatography(HPLC).The results were as follows:the detection limit was 0.005 μg/mL,linear range was 0.005~4 μg/mL.Pharmacokinetic data of the hybrid tilapia plasma conformed to a two-compartment model with first-order absorption in either aqueous solution or medicated feed administration.The pharmacokinetic equation,Ct=0.23e-0.028(t-0.010)+0.353e-0.011(t-0.010)-0.584e-0.468(t-0.010),was for aqueous solution,and Ct=0.839e-0.057(t-0.459)+0.442e-0.013(t-0.459)-1.281e-0.282(t-0.459),for medicated feed.The main pharmacokinetic parameters of the two oral administrations of OTC were respectively as follows:absorption half-life(t1/2ka)=1.481 h for aqueous solution,2.458 h for medicated feed,distribution half-life(t1/2α)=24.834 h,12.193 h,elimination half-life(t1/2β)=60.312 h,51.533 h,Tmax=7.230 h,8.221 h,Cmax=0.494 μg/mL,0.796 μg/mL,AUC=37.744 μg·h/mL,43.075 μg·h/mL.The parameters showed that the hybrid tilapia absorbed OTC quicker via orally aqueous solution administration than via medicated feed,but the oxytetracycline distributed and eliminated slower through aqueous solution administration than via medicated feed.
【Fund】: 广州市白云区科技计划项目(2006-SZ-20)
【CateGory Index】: S948
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