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《Freshwater Fisheries》 2012-04
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Studies on the pharmacokinetics and residues of avermectin in grass carp(Ctenopharyngodon idellus) after single oral administration

QIN Gai-xiao1,XU Wen-yan1,AI Xiao-hui2,TANG Guo-pan1,CUI Jin1, LI Xiang-hui1,YUAN Ke-ping2(1.Zhengzhou College of Animal Husbandry Engineering,Zhengzhou 450011,China; 2.Yangtze River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Wuhan 430223,China)  
A dose(0.1 mg/kg) of avermectin was given to grass carp by oral administration.Tissues(plasma,muscle,Liver) concentration of avermectin were measured by high performance liquid chromatography(HPLC) with fluorescence detector(FD).The plasma concentration-time data was analyzed with 3P97 practical pharmacokinetics software.The results showed that the main parameters in the blood of grass carp were:AUC 1 638.02 μg·h·L-1,Cmax 18.51 μg·L-1,t1/2α 21.77 h,t1/2β218.71 h,Tpeak 24.00 h,k10 0.023 h-1,k12 0.007 3 h-1,k21 0.004 3 h-1.on the fourteen day after dosing,the residues of avermectin in plasma can not be detected,but the depletion of avermectin in muscle and liver need 25 days.
【Fund】: “十一五”国家科技支撑计划“渔药安全使用及快速检测技术研究”项目(2006BAD03B04-04)
【CateGory Index】: S948
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 LONG Qi-Cai1 REN Bin2 LI SHu-Xia2 ZENG Gut--Xiong1 1(Department of Clinical Pharmacology, Sun Yat-sen University of Medical Sciences, Guangzhou 510080) 2(Department of Pharmacy The First Affiliated Hospital, Sun Yat-sen University of Medical Scien-ces, G;Human Pharmacokinetics of Orally Taking Ivermectin[J];The Chinese Journal of Clinical Pharmacology;2001-03
2 Hu Hongbo,Zhu Beilei,Li Junsuo,Wang Jiande, Wang Hongcai,Chen Yingjian,Li Xiwang (College of Veterinary Medicine, China Agricultural University,Beijing 100094);THE PHARMACOKINETICS OF AVERMECTIN B 1 AFTER ORAL ADMINISTRATION TO SHEEP AND RABBITS[J];CHINESE JOURNAL OF ANIMAL AND VETERINARY SCIENCES;1998-05
3 Pan Baoliang, Wang Yuwan, Wang Ming (College of Veterinary medicine , China Agricultural University, Beijing 100094;China);Comparation of Pharmacokinetics of Prolonged Injection and Common Injection of Avermectin in Sheep[J];Chinese Journal of Veterinary Drug;2003-03
4 YI Jin-e,YUAN Hui,TU Di(College of Animal Medicine,HNAU,Changsha Hunan 410128,China);Study on the pharmacokinetics of avermectins microcapsule in rabbits[J];Journal of Traditional Chinese Veterinary Medicine;2008-01
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 SUN Ming-na et al (Key Laboratory of Crop Quality Amelioration in Anhui Province,Hefei,Anhui 230031);Study on the Development Method of Abamectin Residue Determination[J];Journal of Anhui Agricultural Sciences;2006-12
2 PENG Zhang-xiao1,JIANG Min1,2,WU Hao1,HE Lin1,YANG Li1(1.Key Laboratory of Aquatic Genetic Resources and Aquacultural Ecology Certificated by the Ministry of Agriculture,Shanghai Ocean University,Shanghai 201306,China;2.Research and Engineering Center on Aquatic Environment Ecosystem,Shanghai Ocean University,Shanghai 201306,China);Research on the method for ivermectin determination in different crucian tissues[J];Journal of Fisheries of China;2010-06
3 CHEN Jia-zhang1,YANG Guang2,MENG Shun-long1,MA Xiao-yan2,HU Geng-dong1 (1Key Open Laboratory of Ecological Environment and Resources of Inland Fisheries,Freshwater Fisheries Research Center,Chinese Academy of Fishery Sciences,Wuxi 214081,Jiangsu,China;2Fishery Engineering Research Institute,Chinese Academy of Fishery Sciences,Beijing 100141,China);Effects of different concentration avermectin on the catalase and glutathione-S-transferase activities of common carp[J];Chinese Journal of Ecology;2010-04
4 QIN Gai-xiao1,XU Wen-yan1,AI Xiao-hui2,TANG Guo-pan1, CUI Jin1,LI Xiang-hui1,YUAN Ke-ping2(1 Department of Animal Husbandry,Zhengzhou College of Animal Husbandry Engineering,Zhengzhou,He'nan 450011,China; 2 Yangtze River Fisheries Research Institute,Chinese Academy of Fishery Science,Wuhan,Hubei 430223,China);Studies on pharmacokinetics of Avermectin in grass carp(Ctenopharyngodon idellus)[J];Journal of Northwest A & F University(Natural Science Edition);2012-08
5 ZHOU Qi-jia,WANG Jun,NIU Su-fang,JIN Yuan,MAO Yong* (College of Ocean & Earth Sciences,Xiamen University,Xiamen 361005,China);Establishes Method of Avermectin in Four Tissues of Pseudosciaena crocea by High Performance Liquid Chromatography with Fluorescence Detection[J];Journal of Xiamen University(Natural Science);2013-03
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 SUN Ming-na et al (Key Laboratory of Crop Quality Amelioration in Anhui Province,Hefei,Anhui 230031);Study on the Development Method of Abamectin Residue Determination[J];Journal of Anhui Agricultural Sciences;2006-12
2 CUI Chen-xin et al(Henan Institute of Science and Technology,Xinxiang,Henan 453003);Experiment in the Control of Leaf Miner with 1.8 % Abamectin Emulsion[J];Journal of Anhui Agricultural Sciences;2006-20
3 FENG Wu-jian et al(Xuzhou Higher Vocational College of Biological Engineer,Xuzhou,Jiangsu 221151);Efficacy Experiment in the Control of Cossus orientalis Gaede with Biological Pesticides[J];Journal of Anhui Agricultural Sciences;2007-27
4 ;Pharmacokinetics of oral ketoconazole microcapsule in rabbits[J];Academic Journal of Second Military Medical University;2006-07
5 Xie Xianchuan~(*1,2),Zhang Shaohua~(3,4),Wan Dongshen~(2),Huangpu Weiguo~(3),Yang Ting~(3),He Xinhua~3()~1(School of the Environment,Nanjing University,Nanjing 210093)()~2(Plant Protection Research Institute,Shanghai Academy of Agricultural Science,Shanghai Key Laboratory of Protected Horticultural Technology,Shanghai 201106)()~3(Analytical Center of Agricultural Produce Ningbo Academy of Agricultural Science,Ningbo 315040)()~4(Ningbo Superuvision and Inspection Institute for Product Quality.Ningbo 315040);Impact factors of Fluorescence Derivatization Reaction of Abamectin[J];Chinese Journal of Analytical Chemistry;2006-12
6 LONG Qi-Cai1 REN Bin2 LI SHu-Xia2 ZENG Gut--Xiong1 1(Department of Clinical Pharmacology, Sun Yat-sen University of Medical Sciences, Guangzhou 510080) 2(Department of Pharmacy The First Affiliated Hospital, Sun Yat-sen University of Medical Scien-ces, G;Human Pharmacokinetics of Orally Taking Ivermectin[J];The Chinese Journal of Clinical Pharmacology;2001-03
7 Nie Kui Zeng Zhongliang Yu Pengnan et al.;PROGRESS IN RESEARCHES ON AVERMECTINS[J];Journal of Sichuan Institute of Animal Husbandry and Veterinry Medicine;2000-04
8 Ma Chengzhu Wei Chunmei (Plant Protection Research Institute,Shanghai Academy of Agricultural Sciences,Shanghai201106);ANALOGUES AND DERIVATIVES OF AVERMECTINS[J];Acta Agriculturae Shanghai;2000-S1
9 CAO Hong\+1, CHEN Jian\+2, LIU Hong\+1(1 Department of Chemistry, Teachers College, Shihezi University, Shihezi, Xinjiang 832003 China; 2 College of Pharmacy, Xinjiang Medical University, Ulumuqi, Xinjiang 830054, China) ;Pharmacokinetic Properties of Avermectin Long-Acting Injection in Sheep[J];Journal of Shihezi University(Natural Science);2003-02
10 AI Xiao-Hui,LIU Chang-Zheng and ZHOU Yun-Tao (Key Laboratory of Freshwater Fish Germplasm Resources & Biotechnology of Ministry of Agriculture, Yangtze Fisheries Institute,Chinese Academy of Fishery Sciences,Jingzhou 434000; Freshwater Fisheries Research Center,Chinese Academy of Fishery Sciences,Wuxi 214081);A STUDY ON PHARMACOKINETIC OF SULPHAMETHOXAZOLE IN GRASS CARP AT DIFFERENT TEMPERATURES AND ADMINISTRATION REGIMES[J];Acta Hydrobiologica Sinica;2005-02
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