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《Chinese Journal of Control of Endemic Disease》 1990-04
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STUDY ON HEPATIC DAMAGE INDUCED BY PATHOGENIC FACTORS OF KESHAN DISEASE IN THE GRAINS FROM ENDEMIC AREA

Liu Songyan Wang Fan(Institute of Endemic Diseases Norman Bethune University of Medical Sciences, Changchun)  
The content of lipid peroxides (MDA) and the activities of five enzymes were, measured in the livers of the rats fed on grains from Keshan disease endemic area and non-endemic area respectively. The results indicated that the activities of hepatic glutathione peroxidase and thyroxine 5'-monodeiodinase were reduced markedly, and the activity of glutamyl transpeptidase and content of MDA were increased significantly in the rats of the endemic group. These suggest that there exists a hepatic damage in the rats fed on grains from Keshan disease endemic area. The role of hepatic damage in occurrence of cardiac necrosis in the patients with Keshan disease is discussed as a possible mechanism.
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Wang Fan Li Guangsheng An Ruguo Yang Tongshu;Studies on the Pathogenic Factors of Keshan Disease in the Grains Cultivated in Endemic Regions[J];Chinese Journal of Endemiology;1982-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Liu Songyan, Wang Lijuan, Wang Fan(Institute of Endemic Diseases);Effect of lysine on permeability of myocardial sarcolemmal membrane in rats fed with grains from Keshan disease endemic area[J];;1990-01
2 Yang Xiaoju, et alDepartment of Pathologic Anatcmy;HISTOCHEMICAL STUDIES ON THE ENZYMES OF HUMAN HEPATOCELLULAR CARCINOMA AND ITS SURROUNDING TISSUES I. ALTERATIONS OF γ-GTP, G-6 PASE AND ATPASE[J];Academic Journal of Second Military Medical University;1984-03
3 Zhan Rongzhou, et alDepartment of pathologic Anatomy;HISTOCHEMICAL STUDIES ENZYMES OF HUMAN HEPATOCELLUAR CARCINOMA AND ITS SURROUNDING LIVER TISSUES II.ALTERATIONS OF ALKALINE PHOSPHATASE, ACID PHOSPHATASE, 5 '-NUCLEOTSDASE, NON-SPECIFIC ESTERASE AND SUCCINIC DEHYDROGENASE[J];Academic Journal of Second Military Medical University;1984-04
4 Bai Nai-bin (Institute of Environmental Chemistry, Academia Sinica, Beijing);A MULTI-VARIABLE STATISTICAL ANALYSIS OF ECO-ENVIRONMENTAL DATA ON THE DIFFERENT KASCHIN-BECK DISEASE REGIONS IN CHINA[J];Endemic Disease Bulletin;1987-01
5 TAN Wuhong; HUA Luoming; ZHAI Lianbang; YANG Zhantian; XU Guanglu(Research Laboratory of Keshan Disease, Trace Element and Endemic DiseaseResearch Laboratory, Xi'an Medical University, Xi'an 710061);Effect of Selenium Supplementation on Plasma Thyroid Hormone Levels of Residents in a Low-Selenium Keshan Disease Area[J];ENDEMIC DISEASES BULLETIN (CHINA);1998-04
6 Yao Zaiyong Niu Cunlong (Institute of Geochemistry, Academia Sinica);THE ROLE OF TRACE ELEMENT MOLYBDENUM IN PREVENTION OF KESHAN DISEASE——AN EXPERIMENTAL STUDY[J];Geochimica;1984-03
7 Liu Songyan;PROTECTIVE EFFECTS OF SELENIUM AND MOLYBDENUM ON HYPOXIC MYOCARDIAL INJURY[J];Chinese Journal of Control of Endemic Disease;1989-04
8 Wang Li;DETERMINATION OF T_3 AND T_4 IN SERUM OF PATIENTS WITH KESHAN DISEASE AND VIRAL MYOCARDITIS[J];Chinese Journal of Control of Endemic Disease;1989-04
9 Liu Xiaoliang,et al Institute of Endemic Disease, Norman Bethune University of Medical Sciences;CHANGES OF MYOCARDIAL THYROXINE 5'-MONODEIODINASE OF RATS FED GRAINS FROM A KESHAN DISEASE ENDEMIC AREA AND THE PREVENTIVE EFFECTS OF SELENIUM AND VITAMIN E[J];Chinese Journal of Control of Endemic Disease;1994-02
10 Guo Chenghao, et al Institute of Endemic Disease, Norman Bethme University of Medical Sciences, Changchun;EFFECT OF CALCIUM ON THYROID HORMONE METABOLISM OF RATS FED WITH KESHAN MONOTONOUS DIET[J];Chinese Journal of Control of Endemic Disease;1995-02
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 Wang Meina,et al (Department of Pharmacology);THE PROTECTIVE EFFECT OF WU RENCHUN(五仁醇)AGAINST CHRONIC HEPATIC INJURY[J];Journal of Xi'an Jiaotong University (Medical Sciences);1989-03
2 Yang Guang-qi, Wang Guang-ya, Yin Tai-an, Sun Shu-zhuang Zhou Rui-hua, Man Rong-e, Zhai Feng-ying, Guo Shu-hua Wang Hui-Zhen & You De-quan(Institute of Health, Chinese Academy of Medical Sciences, Beijing);RELATIONSHIP BETWEEN THE DISTRIBUTION OF KESHAN DISEASE AND SELENIUM STATUS[J];Acta Nutrimenta Sinica;1982-03
3 Liu Songyan Wang Fan;Change of hepatic deiodination of thyroxine(T4)in rats fed with grain from the endemic area of Keshan disease[J];Chinese Journal of Endemiology;1989-05
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