STUDY ON HEPATIC DAMAGE INDUCED BY PATHOGENIC FACTORS OF KESHAN DISEASE IN THE GRAINS FROM ENDEMIC AREA
Liu Songyan Wang Fan(Institute of Endemic Diseases Norman Bethune University of Medical Sciences, Changchun)
The content of lipid peroxides (MDA) and the activities of five enzymes were, measured in the livers of the rats fed on grains from Keshan disease endemic area and non-endemic area respectively. The results indicated that the activities of hepatic glutathione peroxidase and thyroxine 5'-monodeiodinase were reduced markedly, and the activity of glutamyl transpeptidase and content of MDA were increased significantly in the rats of the endemic group. These suggest that there exists a hepatic damage in the rats fed on grains from Keshan disease endemic area. The role of hepatic damage in occurrence of cardiac necrosis in the patients with Keshan disease is discussed as a possible mechanism.