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《Chinese Journal of Control of Endemic Disease》 1993-03
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ASSESSMENT OF HUMAN HEALTH EFFECTS CONCERNED WITH EXPOSURE TO INDOOR AIR FLUORIDE CAUSED BY BURNING HIGN FLUORIDE COAL

Yang Xiaoping, et al The Institute of Environmental Medicine, Tong ji Medical University  
This research is to assess the human health effects exposed to excessive fluoride and the prevention effects after reduced fluoride exposure in the endemic fluorosis areas. 59 children under 10 years old are selected to test lacate dehydrogenase (LDH) and isoenzymes.alkaline phosphatase (AKP), superoxide dimutase (SOD) in serum and glutathione peroxidase (GSH-Px) in blood. The children come from three villages:nonreformed stove village (NR) with high air and food fluoride polluted ; reformed stove village (R) with using the reducing-fluoride-stove for about 5 years;and control village (C)without fluoride polluted. The results show the LDH and AKP activities in the children of NR village are higher than that of children in C and R villages. There are significant differences by statistic analysis (P0.01 ), there probably has a threshold in the effect of fluoride on LDH and AKP activities and LDH and AKP are sensitive biomarkers to assess the human health effects caused by fluoride and to estimate the preveotion effects after reduced fluoride exposure. Because LDH and AKP activities are effected by many factors, fluoride load and time of fluoride exposure must be considered when using LDH and AKP as biomarkers for fluorosis.
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