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《Chinese Journal of Control of Endemic Disease》 2004-03
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Combined effects of vitamin E and fluoride on reproductive function in male mice

AN Li,QIAN Cong,ZHANG Zhi-yu,et al (Dept. of Epidemiology,School of Public Health,China Medical University,Shenyang 110001)  
Objective To study combined effects of vitamin E (VE) and fluoride on reproductive function in male mice. Methods According to their body weights, adult male mice were randomly divided into 5 groups with each 10 mice: blank, VE control, VE antagonism, NaF1 and NaF2 group. Sodium fluoride (NaF) was given to mice by dissolving in deionized drinking water with 200 mg/L (VE antagonism and NaF1 group) or 300 mg/L (NaF2 group), and VE was given by oral gavage with 200 mg/kg (VE control and VE antagonism). Mice were observed every day and body weights were measured every week. 5 weeks later, levels of serum fluoride were examined. Epididymal and testicular viscera coefficient, sperm count, sperm mobility, sperm malformation were also measured. Results Majority of mice emerged dental fluorosis in NaF2, NaF1 and VE antagonism group from 3 to 5 weeks, but no significant difference was observed among them(P0.05). The level of serum fluoride in NaF2 is higher obviously than those in other groups(P0.01). Levels of serum fluoride in NaF1 and VE antagonism group are also higher obviously than those in blank and VE control group(P0.01).There were no significant differences in body weight, epididymal and testicular viscera coefficient, sperm count of epididymis, sperm malformation among all groups(P0.05). The ratios of viable sperm and sperm mobility in NaF2, NaF1 and VE antagonism group were lower significantly than those in blank and VE control group(P0.05 or P0.01). Conclusions 200 or 300 mg/L sodium fluoride in drinking water can significantly decrease sperm count and mobility of male mice. VE were given while administrated with NaF, effects mentioned above of mice have not been improved.
【CateGory Index】: R96
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