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《Chinese Journal of Control of Endemic Disease》 2004-05
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The experimental study of selenium on the protective effect in organism injury caused by fluoride

BIAN Jian-chao , XIAN Shu-mei, YE Ping, et al (Shandong Institute for Prevention and Treatment of Endemic Disease,jinan 250014)  
Objective To study the protective effect and explore the protective mechanism of selenium(Se) on organism injury caused by fluorine. Methods 2 groups of Wistar rat with chronic fluorosis were duplicated with 2 concentration of fluorine(F 30 mg/L and 50 mg/L)in drinking water. At the same time,selenium (Se 2.0 mg/kg )was supplemented in 2 groups of rat with fluorosis for 14 months. The amount of drinking water and diet, the excretion of urine and the contents of urine F were tendentiously surveyed every month in one year. The X-ray was taken in every 2 months for 6 times. The contents of Se and F, the parameters of bone histomorphometry, the contents of free radicals, the anti-oxidation enzymes, the thyroid hormones, the parameters of electrocardiogram and electrophysiology myocardial cells were determined during the experimental period of 4, 8, 14 months. Results After supplement of Se, the condition of food and drink improved, the weight rose, the amount of urine excretion heightened and F of the bone and tissues decreased. The occurrence of skeletal fluorosis was delayed and the obstruction of bone mineralization was restrained. The restoration of the anti-oxidation enzymes activity, the adjustment of thyroid hormones level and the disnormal of antagonism in electrocardiogram and electrophysiology myocardial cells were observed in the rats with fluorosis. Conclusions Se in the range of certain concentration might be antagonize high fluorine and the promotion of urine excretion, the protection of bone system, the disorder of correction in the free radicals metabolism and the effect on the liver, kidney and myocardial cells were the important mechanism of Se in antagonism with F.
【Fund】: 山东省卫生厅资助项目No .1 992 0 2 4
【CateGory Index】: R599
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