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《Chinese Journal of Control of Endemic Disease》 2004-06
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Study on the cardiovascular damage of skeletal fluorosis patients

JI Fang, XU Hong, ZHANG Yue-xin, et al (School of Public Health, Xinjiang Medical University,Wulumuqi 830054)  
Objective In order to comprehend the long-term effects on the cardiovascular damage of skeletal fluorosis patients after stopping exposure to excessive amount of fluoride.Methods 65 cases of the patients with different degree skeletal fluorosis,and 23 residents without skeletal fluorosis as contrast were surveyed in their history of cardioangiopathy and checked by blood pressure and electrocardiography. Results The skeletal fluorosis patients' abnormal rate of cardiovascular system symptom was 70.77%, but no different in statistics between patients and the control(P0.05); The rate of cardiovascular system symptom has increasing with becoming heaver the disease degree of skeletal fluorosis, and the per-items' abnormal rates of the severe group were significantly higher than those of normal control (P0.05). The abnormal rate of electrocardiogram (ECG) of the patient group was higher than that of normal control (42 cases,35.38%;17 cases 26.09%),but no different in statistics (P0.05).The comparison of parameter of ECG shows that the P-R interval of the severe patients group were significantly longer than that of normal control (P0.05).The blood pressure were no different in statistics(P0.05) between patients with skeletal fluorosis and the control. Conclusions Fluorine has certain long-term hazardous effect on the patients' cardiovascular system although the patients with skeletal fluorosis had stopped drinking high fluoric water for eighteen years. The changes of ECG can be recovered in the mild skeletal fluorosis patients, but in the severe patients these changes recovered slower. Which kinds of long-term hazardous effect on the cardiovascular of the severe skeletal fluorosis patients,we still have a long way to go to catch up with.
【Fund】: 国家自然科学基金项目 (编号 :30 1 60 0 79)
【CateGory Index】: R599.9
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