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《Journal of First Military Medical University》 1993-01
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A study on the beneficial effects of “Uraemic Clearance” on experimental chronic renal failure in rats

Deng Hongzhu.Chen Zhiliang, Shi Xinghua Pharmaceutical Department, Nanfang Hospital  
A rat model of chronic renal failure, induced by feeding chow containing 0.5% adenine for 8 weeks, produced uremic signs resembling those observed in humans with end-stage renal diseases, such as azotemia, renal anemia and metabolic perturbation of electrolytes. After two weeks of adenine feeding, "Ura-emic Clearance ( UC ) " in two dose levels of 3.75 and 1.25g/kg was given ig to the rats for six weeks. The results indicated that UC given orally had pronounced therapeutic effects on rats with chronic renal failure. In comparison to the untreated control group,blood urea nitrogen and sehum creatinine mean levels in UC-treated groups were markedly lower (P0.05) , and HGB 、RBC、 HCT mean values were significantly higher (P0.05) , Hyperphosphatemia and hypocalcemia characteristic of renal failure were improved to some extent.The pathological findings revealed that the kidney weight and numler of crystals of adenine metabolite in kidney of UCtreated groups decreased markedly as compared with those of the adeninefed controls (P0.01); the proliferation of fibroid tissue was alleviated and the mi-croscopic features of renal tubules tend to become normal.
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