Initial study on angiogenesis of primary hepatocellular carcinoma
CHENG Tian-ming1, PAN Shi-lei2, LIU Xiao-xia1, YUAN Ai-li1, LI Chao-long3 (Institute of Digestive Diseases, Department of Hepatobiliary Surgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China; Department of Obstetrics and Gyn
Objective To study the angiogenesis of primary hepatocellular carcinoma (PHC). Methods The blood vessel formation in the cancerous and adjacent normal liver tissues in 21 patients with PHC were studied by pathological and immunohistochemical examinations (CD34 and Ulex europaeus agglutinin 1,UEA-1). Results The positive staining of CD34 and UEA-1 could not be seen in liver sinusoidal endothelial cells of patients with liver cirrhosis chronic hepatitis, but could be seen in the vessels in inflammatory tissues. The endothelial cells showed marked staining for CD34 and UEA-1 PHC. The tumor vessels had continuity with the vessels in tissues adjacent to PHC in some regions. Conclusion The PHC vessels might be derived from the capillarized liver in the parineoplastic liver tissues sinusoid.
【CateGory Index】： R735.7