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Effects of neutral jujube date polysaccharide on the proliferation of rat splenocytes

ZHANG Qing, LEI Lin-sheng, YANG Shu-qin, SUN Li-sha (Department of Pharmacy, Nanfang Hospital, Department of Pharmacology, First Military Medical University, Guangzhou 510515,China)  
Objective: To study the effects of neutral jujube date polysaccharide (JDP-N) on the proliferation of rat splenocytes and [Ca2+], in concanavali-A (ConA)-activated spelnocytes. Methods The proliferation of rat splenocytes was determined by MTT assay and [Ca2+]. by laser scanning confocal microscope. Results JDP-N promoted the auto-proliferation of the splenocytes and enhanced mined lymphocyte reaction. In contrast, the proliferation of ConA-activated splenocytes did not undergo any visible changes in response to JDP-N treatment When interleukin-2 was present, nor was the [Ca2+]i in the ConA-activated splenocytes responding. Conclusion JDP-N can only promote the proliferation of non-activated splenocytes in rats.
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