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《Journal of First Military Medical University》 2003-01
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Preparation of famotidine microemulsion and its quality evaluation

YE Hai-ying 1 , ZHANG Zhong-yi 1 , GAO Shen 2 , LU Ying 2 , WANG Yan 11 Department of Pharmacy, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China; 2 Department of Pharmaceutics, College of Pharmacy, Second Military Medical University, Shanghai 200433, China  
Objective To study the preparation of famotidine microemulsion (FM) and its quality evaluation, thereby to establish the quality-control criteria for this preparation. Methods The formulations of the FM were optimized by studying the pseudoternary phase diagrams and its absorption in rat jejunum using in situ perfusion method. The morphology, particle size distribution, famotidine concentration and stability of the FM were studied. Results The optimization of formulation was completed successfully. Electron microscopy presented the FM as small spherical drops, with a mean diameter of 65 nm. The average recovery as determined by high-performance liquid chromatography was 97.63%, its mean RSD being 0.72%. Conclusion The FM is easy to prepare with consistent quality, whose reliable determination method may be easily reproduced.
【CateGory Index】: R944.1
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